Investigation of transforming growth factor β1 in induced sputum and nasal secretion in children with bronchial asthma

Turovskaya A.A., Kostina E.M., Levashova O.A., Orlova E.A., Trushina E.Yu., Molotilov B.A., Nefedova T.A.

1) Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; 2) Clinical Hospital No. 4, Penza, Russia

Background. The problem of finding reliable markers of bronchial asthma (BA) severity in children is relevant. It is of interest to evaluate the production of TGF-β1 (transforming growth factor β1) in induced sputum and nasal secretion in predicting the BA severity in children. Objective. Investigation of the TGF-β1 level in induced sputum and nasal secretion in children with allergic bronchial asthma of varying severity. Methods. The concentration of TGF-β1 in induced sputum and nasal secretion was determined using enzyme-linked immunosorbent assay. Results. The production of TGF-β1 in induced sputum significantly differed in the groups of children with bronchial asthma compared to the control group (Kruskal-Wallis test, p<0.05) and between themselves (Kruskal-Wallis test, p<0.05). No dependence of the TGF-β1 level in nasal secretion on the severity of bronchial asthma was found. Conclusion. The TGF-β1 level in induced sputum correlates with the severity of bronchial asthma in children, which reflects the intensity of inflammation in the lower respiratory tract and the dynamics of progressive bronchial remodeling. Investigation of TGF-β1 in induced sputum for identifying the severity of bronchial asthma in children is promising area.

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About the Authors

Corresponding author: Alina A. Turovskaya, Postgraduate Student, Department of Allergology and Immunology with a Course in Dermatovenereology and Cosmetology, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; alinaziboreva@yandex.ru

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