Phenotype of bronchial asthma with fixed obstruction

Kostina E.M., Trushina E.Yu., Tipikin V.A., Orlova E.A.

Penza Institute for Advanced Training of Physicians – Branch Campus of RMACPE, Penza, Russia

A characteristic feature of bronchial asthma (BA) is reversible airflow obstruction, which is quickly relieved by short-acting bronchodilators. However, incomplete reversibility (spirometry results do not return to normal despite treatment), also called fixed bronchial obstruction (FBO), occurs in 60% of patients with severe asthma. Patients with asthma with FBO represent a special cohort characterized by a severe course of the disease and reluctance to therapy with high doses of inhaled corticosteroids. The phenotype of BS with FBO requires additional study to determine the volume and choice of therapy.

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About the Authors

Corresponding author: Elena Yu. Trushina, Cand. Sci. (Med.), Associate Professor at the Department of Pulmonology and Phthisiology, Penza Institute for Advanced Medical Studies – Branch Campus of RMACPE, Penza, Russia, trushina.lena@mail.ru 

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