Efficacy of probiotic use in children

Zakharova I.N., Pupykina V.V.

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Saccharomyces boulardii CNCM I-745 (Enterol®) is a probiotic yeast strain whose eukaryotic nature provides a number of clinically significant advantages. These include natural resistance to antibacterial drugs, stability during passage through the acidic environment of the gastrointestinal tract, and the absence of the ability to horizontally transfer antibiotic resistance genes. Its therapeutic effect is mediated through a multicomponent pathogenetic mechanism: direct microbial competition, neutralization of bacterial toxins, stimulation of reparative processes in the intestinal epithelium, and modulation of the local immune response. The efficacy of Saccharomyce boulardii CNCM I-745 in acute gastroenteritis and antibiotic-associated diarrhea has been proven in pediatric practice, as confirmed by randomized trials and enshrined in the ESPGHAN and World Gastroenterology Organization (WGO) consensus guidelines. The adjuvant use of this strain in Helicobacter pylori eradication regimens in children was separately analyzed: inclusion of the drug in combination therapy statistically significantly reduces the incidence of dyspeptic and systemic adverse events, ensuring high compliance and completion of the full course of treatment.

For citations: Zakharova I.N., Pupykina V.V. Efficacy of probiotic use in children. Pharmateca. 2026;33(3):113-120. (In Russ.). DOI: 
https://dx.doi.org/10.18565/pharmateca.2026.3.113-120

Authors’ contribution: All authors made an equivalent contribution to the preparation of the publication.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

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About the Authors

Irina N. Zakharova, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; zakharova-rmapo@yandex.ru, ORCID:
https://orcid.org/0000-0003-4200-4598
Viktoria V. Pupykina, Cand. Sci. (Med.), Teaching Assistant, Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; vika-pupykina@mail.ru, ORCID: https://orcid.org/0000-0003-2181-8138 (corresponding author)

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