Current approaches to treating irritable bowel syndrome in children
Zakharova I.N., Pupykina V.V., Berezhnaya I.V.
Irritable bowel syndrome (IBS) in children is characterized by significant prevalence and a variety of clinical manifestations. Its development is primarily influenced by disruptions in the microbiota-gut-brain system, the development of visceral hypersensitivity, and combined motility and neuroimmune disorders. Current therapeutic approaches include dietary interventions (including low-FODMAP and various elimination diets) in combination with drug therapy aimed at correcting motor, sensory, and inflammatory changes. One promising pharmacological approach involves targeting the enkephalinergic system, which is involved in the peripheral regulation of gastrointestinal functions. Trimebutine (Trimedat®) exhibits properties as a multifactorial regulator of motility and visceral sensitivity, ensuring physiological adaptation of impaired functions without suppressing normal reflex mechanisms. Results of randomized controlled trials demonstrate its clinical efficacy in reducing abdominal pain, normalizing motor-evacuation function, and improving patients’ quality of life.
For citations: Zakharova I.N., Pupykina V.V., Berezhnaya I.V. Current approaches to treating irritable bowel syndrome in children. Pharmateca. 2026;33(3):70-77. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.3.70-77
Authors’ contribution: All authors made an equivalent contribution to the preparation of the publication.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Keywords
children
gastrointestinal tract
trimebutine
irritable bowel syndrome
microbiota-gut-brain
enkephalinergic system
About the Authors
Irina N. Zakharova, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; zakharova-rmapo@yandex.ru, ORCID:https://orcid.org/0000-0003-4200-4598
Viktoria V. Pupykina, Cand. Sci. (Med.), Teaching Assistant, Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; vika-pupykina@mail.ru, ORCID: https://orcid.org/0000-0003-2181-8138 (corresponding author)
I.V. Berezhnaya, Cand. Sci. (Med.), Associate Professor, Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; berezhnaya-irina26@yandex.ru, ORCID: https://orcid.org/0000-0002-2847-6268
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