Dynamics of ICF domains in children with acute rhinosinusitis and allergic rhinitis under different comprehensive treatment regimens

Filatova E.V., Khrykova A.G., Ivanova I.I.

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia

Background: Acute rhinosinusitis and allergic rhinitis in children are associated not only with local inflammatory changes in the mucous membrane of the nasal cavity and nasopharynx, but also with functional impairments affecting sleep, emotions, sensory perception, breathing, speech, learning, and daily activity.
Objective: To assess changes in International Classification of Functioning, Disability and Health (ICF) categories and domains in children with acute rhinosinusitis and allergic rhinitis under different comprehensive treatment regimens.
Materials and methods: A prospective comparative non-randomized study included 454 children aged 3–18 years: 320 with acute rhinosinusitis (ARS) and 134 with allergic rhinitis (AR). All groups received drug therapy; Group 2 also received laser therapy, and Group 3 received laser therapy and Fermenkol ultraphonophoresis. Fourteen ICF outcomes were assessed before treatment and on days 10–11. Within-group changes, magnitude of improvement (Δ* = before − after), and the proportion with Δ*>0 were analyzed.
Results: After FDR-BH correction, between-group differences in Δ* were significant for 13 of 14 outcomes in ARS and all 14 in AR (q<0.05). The largest ε² values were observed for structures involved in voice and speech (0.498) and learning (0.420) in ARS, and taste (0.449) and smell (0.404) in AR. Improvement rates in Groups 1/2/3 were 44/34/97% for learning in ARS (Cramér’s V=0.573) and 23/29/69% for social life in AR (V=0.418); both q<0.001. Group 3 showed greater improvement than Group 2 for 13 outcomes in ARS and 10 in AR (Dunn–Holm, p<0.05).
Conclusion: ICF scores characterize functional changes during treatment in children with ARS and AR. Combined physiotherapy was associated with greater improvement in most outcomes.

For citations: Filatova E.V., Khrykova A.G., Ivanova I.I. Dynamics of ICF domains in children with acute rhinosinusitis and allergic rhinitis under different comprehensive treatment regimens. Pharmateca. 2026;33(7):80-87. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.7.80-87

Authors’ contribution: E.V. Filatova – formulation of the scientific hypothesis, scientific consulting at all stages, critical analysis of the data obtained, and final approval of the manuscript before submission to the journal. A.G. Khrykova – study concept and design, data collection, research methodology, statistical analysis, and drafting and editing of the manuscript. I.I. Ivanova – assistance with data collection, methodological support, analysis of the data obtained, contribution to the development of the article’s concept, editing of the manuscript, and revision of the English-language text.
Conflicts of interest: A.G. Khrykova and E.V. Filatova are co-inventors of the invention described in patent RU 2798699 C1, «Method for treating Eustachian tube dysfunction.» The authors have no financial or contractual relationships with the manufacturer of Fermencol. The authors declare no other conflicts of interest.
Funding: The parents or legal guardians of all minor participants signed a voluntary informed consent form for participation in the study and for the processing of personal data.
Ethical Approval: The study was approved by the local ethics committee of the Central State Medical Academy of the Presidential Administration of the Russian Federation (protocol No. 2/2022 dated February 15, 2022).
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.

Keywords

About the Authors

Elena V. Filatova, Dr. Sci. (Med.), Associate Professor, Professor at the Department of Physical and Rehabilitation Medicine with a course in Clinical Psychology and Pedagogy, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; 7533200@mail.ru, ORCID: https://orcid.org/0000-0003-3732-6680, eLibrary SPIN: 5470-1139
Anna G. Khrykova, Cand. Sci. (Med.),Associate Professor at the Department of Physical and Rehabilitation Medicine with a course in Clinical Psychology and Pedagogy, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; Anna-Khrykova@mail.ru, ORCID: https://orcid.org/0000-0002-2103-9196, eLibrary SPIN: 1839-6638 (corresponding author)
Irina I. Ivanova, Dr. Sci. (Med.), Professor at the Department of Physical and Rehabilitation Medicine with a course in Clinical Psychology and Pedagogy, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia;
i.ivanova@mail.ru, ORCID: https://orcid.org/0000-0002-8943-9321, eLibrary SPIN: 6308-1355

Similar Articles