Anogenital psoriasis: literature review and clinical case

Khryanin A.A., Alyavi S.F., Sokolovskaya A.V., Chernikova E.V., Rakhmatov A.B.

1) Novosibirsk State Medical University, Novosibirsk, Russia; 2) RPO “Association of Obstetricians-Gynecologists and Dermatovenerologists”, Novosibirsk, Russia; 3) Tashkent State Dental Institute, Tashkent, Republic of Uzbekistan; 4) Republican Specialized Scientific and Practical Medical Center of Dermatology, Venereology and Cosmetology, Tashkent, Republic of Uzbekistan

Psoriasis is one of the most common dermatological diseases in the world. With a global prevalence of 2–5%, psoriasis can affect all age groups of the population. At the same time, the disease has a significant negative impact on the quality of life of patients, especially when the skin is affected in the anogenital area. The prevalence of isolated anogenital psoriasis (AGP) is estimated at 2 to 5% of all patients with psoriasis. However, generalized plaque or intertriginous psoriasis also affects the genital skin in 29–40% of cases. In addition, the prevalence of AGP is probably underestimated due to the reluctance of both patients and health care providers to discuss anogenital localization and quality of life. As a rule, AGP is associated with significant general and sexual quality of life impairments, higher rates of depression. Sexual dysfunction, decreased frequency of sexual activity and avoidance of intimate relationships are the result of not only objective symptoms (e.g., cracks or pain during/after sexual activity) but also psychosocial effects (embarrassment, fear of stigmatization). It should be noted that AGP symptoms affect the patient’s daily life, social, psychological and work aspects of life. The authors dwell in detail on the features of clinical manifestations of AGP, illustrating them with examples from their own practice. Particular attention in the review is paid to methods of topical and systemic treatment of AGP (including genetically engineered biological drugs). The authors conclude that AGP is often left without due attention, and timely prescription of therapy leads to a significant improvement in the quality of life of patients

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About the Authors

Aleksey A. Khryanin, Dr. Sci.(Med.), Professor, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University; President of the RPO «Association of Obstetricians-Gynecologists and Dermatovenerologists», Novosibirsk, Russia; khryanin@mail.ru, ORCID: https://orcid.org/0000-0001-9248-8303 (corresponding author)
Saidnairkhon F. Alyavi, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Tashkent State Dental Institute, Tashkent, Republic of Uzbekistan; ORCID: https://orcid.org/0009-0003-4128-0387
Asya V. Sokolovskaya, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; ORCID: https://orcid.org/0000-0002-3131-7874
Evgeniya V. Chernikova, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; ORCID: https://orcid.org/0000-0002-9297-6064
Akram B. Rakhmatov, Dr. Sci.(Med.), Professor, Republican Specialized Scientific and Practical Medical Center of Dermatology, Venereology and Cosmetology, Tashkent, Republic of Uzbekistan; ORCID: https://orcid.org/0009-0005-7416-1223

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