The impact of vitamin D deficiency on the clinical course of psoriasis in patients with metabolic syndrome
Mylnikova E.S., Ufimtseva M.A., Popov A.A., Bochkarev Yu.M.
Background: Metabolic syndrome (MS) is associated with the severity of psoriasis. Vitamin D deficiency is highly prevalent in patients with MS. However, conflicting data remain regarding the impact of low vitamin D levels on the clinical features of psoriasis in patients with MS.
Objective: Evaluation of the impact of vitamin D deficiency on the clinical features of psoriasis in patients with MS.
Materials and methods: A total of 136 patients with moderate to severe psoriasis aged over 18 years were examined, including anthropometric data, the PASI index, and a diagnosis of metabolic syndrome (MS). Laboratory tests included a biochemical blood test with a lipid profile and 25(OH)D levels.
Results: Patients with severe psoriasis were more likely to have MS and its components: abdominal obesity (p=0.015 in men; p=0.007 in women), hypertriglyceridemia in men (p=0.038), and arterial hypertension and impaired glucose tolerance in women (p=0.027 and p=0.018, respectively). In patients with psoriasis, 25(OH)D levels correlated with the severity of the dermatosis (p=0.011 in men and p<0.001 in women). Vitamin D deficiency in patients with psoriasis was associated with metabolic syndrome and its components: abdominal obesity (p=0.043 in men; p=0.003 in women), hypertriglyceridemia (p=0.028 in men; p=0.008 in women), and arterial hypertension in women (p=0.022).
Conclusion: Metabolic syndrome correlates with psoriasis severity in both men and women. Vitamin D levels are associated with the severity of the dermatosis. Vitamin D status is associated with metabolic syndrome and its components.
For citations: Mylnikova E.S., Ufimtseva M.A., Popov A.A., Bochkarev Yu.M. The impact of vitamin D deficiency on the clinical course of psoriasis in patients with metabolic syndrome. Pharmateca. 2026;33(5):74-81. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.5.74-81
Authors’ contribution: E.S. Mylnikova, M.A. Ufimtseva – study concept and design. E.S. Mylnikova, A.A. Popov – data collection and processing. E.S. Mylnikova – statistical analysis. E.S. Mylnikova, A.A. Popov, M.A. Ufimtseva – writing the text. M.A. Ufimtseva, A.A. Popov, Yu.M. Bochkarev – editing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Ethical Approval: This study was approved by the local ethics committee of the Ural State Medical University of the Ministry of Health of the Russian Federation, protocol No. 3 dated March 17, 2023.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
Keywords
psoriasis
metabolic syndrome
vitamin D deficiency
abdominal obesity
About the Authors
Ekaterina S. Mylnikova, Dermatovenereologist, Day Hospital Department, Sverdlovsk Regional Dermatovenereology Dispensary; Teaching Assistant, Department of Dermatovenereology and Life Safety, Ural State Medical University, Yekaterinburg, Russia; e.s.mylnikova@mail.ru, ORCID:https://orcid.org/0000-0001-8620-4044, Scopus ID: 57222529229, eLibrary SPIN: 5101-0075 (corresponding author)
M.A. Ufimtseva, Dr. Sci. (Med.), Professor, Chief Physician, Sverdlovsk Regional Dermatovenereology Dispensary; Head of the Department of Dermatovenereology and Life Safety, Ural State Medical University, Yekaterinburg, Russia; mail-m@mail.ru, ORCID: https://orcid.org/0000-0002-4335-9334, Scopus ID: 57193907271, eLibrary SPIN: 4753-7210
A.A. Popov, Dr. Sci. (Med.), Professor, Head of the Department of Hospital Therapy, Director of the Institute of Clinical Medicine, Ural State Medical University, Yekaterinburg, Russia; art_popov@mail.ru, ORCID: https://orcid.org/0000-0001-6216-2468, Scopus ID: 24390984000, eLibrary SPIN: 5083-9389
Yu.M. Bochkarev, Cand. Sci. (Med.), Associate Professor, Associate Professor at the Department of Dermatovenereology and Life Safety, Ural State Medical University, Yekaterinburg, Russia; bochkarev.ju.m@gmail.com, ORCID: https://orcid.org/0000-0001-6298-7216, Scopus ID: 57202803341, eLibrary SPIN: 3830-2810
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