Severe diabetic autonomic neuropathy in a young female patient with type 1 diabetes mellitus: a case report

Volkova A.R., Khalimov Yu.Sh., Chernaya M.E., Lisker A.V., Ostroukhova E.N., Orlovskaya A.D.

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia

This clinical case report aims to expand our understanding of the clinical features of various forms of autonomic neuropathy in type 1 diabetes mellitus. This review describes a combination of various forms of diabetic autonomic neuropathy in a young female patient with type 1 diabetes mellitus who had inadequate glycemic control throughout the disease course. Due to the long-term impact of the neuropathy on the functioning of various internal organs, the patient developed independent disorders affecting the cardiovascular, urinary, and gastrointestinal systems. Autonomic neuropathy, in turn, led to deterioration of glycemic control, which worsened the course of diabetes complications and created a «vicious cycle».

For citations: Volkova A.R., Khalimov Yu.Sh., Chernaya M.E., Lisker A.V., Ostroukhova E.N., Orlovskaya A.D. Severe diabetic autonomic neuropathy in a young female patient with type 1 diabetes mellitus: a case report. Pharmateca. 2025;32(8):112-118. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.8.112-118

Authors’ contribution: Volkova A.R., Khalimov Yu.Sh. – review of critically important content, approval of the manuscript for publication. Ostroukhova E.N., Lisker A.V. – patient selection, examination, and treatment, collection of clinical material, processing, review of critically important content. Chernaya M.E., Orlovskaya A.D. – patient selection, examination, and treatment, collection of clinical material, processing, analysis, and interpretation of data, review of publications on the topic of the article, writing the manuscript.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.

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About the Authors

Anna R. Volkova, Dr. Sci. (Med.), Professor, Department of Therapy, Faculty of Medicine with a Course in Endocrinology, Cardiology, and the G.F. Lang Clinic, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia; volkovaa@mail.ru, ORCID: https://orcid.org/0000-0002-5189-9365
Yury Sh. Khalimov, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Chief Endocrinologist of the Healthcare Committee of the Government of St. Petersburg, Chief Endocrinologist of the Ministry of Defense of the Russian Federation, Head of the Department of Faculty Therapy with a Course in Endocrinology, Cardiology and the G.F. Lang Clinic, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia; yushkha@gmail.com, ORCID: https://orcid.org/0000-0002-7755-7275
Maria E. Chernaya, Cand. Sci. (Med.), Assistant Professor, Department of Faculty Therapy with a Course in Endocrinology, Cardiology and the G.F. Lang Clinic, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia; mashaeatworld@gmail.com, ORCID: https://orcid.org/0000-0001-6567-6990
Anna V. Lisker, Head of the Endocrinology Department, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia;
a.lisker@mail.ru, ORCID: https://orcid.org/0000-0003-4295-1202
Elena N. Ostroukhova, Cand. Sci. (Med.), Associate Professor, Department of Faculty Therapy with a Course in Endocrinology, Cardiology and the G.F. Lang Clinic, Pavlov First SaintPetersburg State Medical University, St. Petersburg, Russia; elenikos9@gmail.com, ORCID: https://orcid.org/0000-0002-6542-7959
Anastasia D. Orlovskaya, Endocrinologist, Clinic of the Scientific and Clinical Center of Endocrinology, Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia; nastyeagle@yandex.ru, ORCID: https://orcid.org/0000-0003-2574-6418 (corresponding author)

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