Current approach to vitamin D deficiency therapy in children with digestive diseases

Mubarakshina O.A., Zhdanova O.A., Batishcheva G.A., Somova M.N., Cherenkova O.V.

Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia

This article examines vitamin D deficiency in children as a significant risk factor for mineral metabolism disorders, as well as immune and metabolic disorders. Despite the implementation of preventive programs, the high prevalence of vitamin D deficiency in the pediatric population, including in the Russian Federation, is highlighted. Particular attention is paid to children with gastrointestinal diseases, in whom deficiency develops due to impaired absorption of fat-soluble vitamins.
The mechanisms of vitamin D absorption and the role of micellar solubilization involving bile acids are analyzed. It has been shown that micelle formation processes are impaired in cholestasis, malabsorption, and other gastrointestinal pathologies, reducing vitamin D bioavailability and increasing the risk of clinically significant deficiency.
This article examines current approaches to correcting vitamin D deficiency, including the use of micellar and nanoemulsion formulations with improved bioavailability. Clinical and experimental data confirming the efficacy of such formulations, particularly in patients with digestive disorders are presented. It is concluded that innovative vitamin D formulations are beneficial in pediatric practice to enhance the prevention and treatment of deficiency, as well as improve therapy adherence.

For citations: Mubarakshina O.A., Zhdanova O.A., Batishcheva G.A., Somova M.N., Cherenkova O.V. Current approach to vitamin D deficiency therapy in children with digestive diseases. Pharmateca. 2026;33(1):82-89. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.1.82-89

Authors’ contribution: Article concept and design – O.A. Mubarakshina. Material collection and processing – O.V. Cherenkova, M.N. Somov. Text writing – O.A. Mubarakshina, O.A. Zhdanova. Scientific editing – G.A. Batishcheva, M.N. Somova.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

Keywords

About the Authors

Olga A. Mubarakshina, Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; mubarakshina@mail.ru, ORCID: https://orcid.org/0000-0001-6799-6322 (corresponding author)
Olga A. Zhdanova, Dr. Sci. (Med.), Associate Professor, Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; olga.vr9@yandex.ru, ORCID: https://orcid.org/0000-0002-3917-0395
Galina A. Batishcheva, Dr. Sci. (Med.), Professor, Head of the Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; bat13@mail.ru, ORCID: https://orcid.org/0000-0003-4771-7466
Marina N. Somova, Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; somova_marina@inbox.ru, ORCID: https://orcid.org/0000-0002-6511-4098
Olga V. Cherenkova, Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; cherenkova.o.v@yandex.ru, ORCID: https://orcid.org/0000-0001-5320-2720

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