The evolution of the role of lytic cocktail in the management of hyperthermia in children in outpatient practice: a retrospective analysis from 2022 to 2024
Bezrukova D.A., Filipchuk A.V., Osmaeva Z.Sh., BezrukovaD.D., Ivannikova V.V.
Background: Despite the expansion of the arsenal of antipyretic and analgesic agents, the effective and safe management of acute conditions such as hyperthermia remains a pressing issue in pediatrics.
Objective: Analysis of the efficacy, safety, and feasibility of using a lytic cocktail in pediatric practice to optimize emergency care.
Materials and methods: A retrospective analysis of 7,050 visits for hyperthermia to the emergency department of Children’s City Polyclinic No. 1 of the Arkhangelsk Region was conducted from 2022 to 2024. Call cards (Form No. 120/u) and site visit logs were analyzed using mathematical and statistical analysis.
Results: Over the study period, a steady decline in the use of lytic cocktail was observed: from 28% in 2022 to 12% in 2024. In absolute numbers, the lytic cocktail was used in 1,304 cases (18.5%) over the entire period. This decrease in use correlated with active public health education efforts initiated in 2023, which led to an increase in the percentage of successful hyperthermia management at home. The lytic cocktail demonstrated high efficacy: the ьуфт time to reduce body temperature by 1.5°C was 22.4±6.7 minutes. By 2024, its use became more selective: for true resistance to oral therapy (71% of cases) and «white» fever (29%). Adverse events were recorded in 8 cases (0.6%) and were transient.
Conclusion: The lytic cocktail remains a highly effective and safe emergency treatment for persistent hyperthermia in children. However, its role has shifted from a routine method to a strictly reserved drug. Systematic educational work with parents and medical personnel has become a key factor in optimizing its use, confirming the high importance of educational programs in modern pediatrics.
For citations: Bezrukova D.A., Filipchuk A.V., Osmaeva Z.Sh., BezrukovaD.D., Ivannikova V.V. The evolution of the role of lytic cocktail in the management of hyperthermia in children in outpatient practice: a retrospective analysis from 2022 to 2024. Pharmateca. 2026;33(3):94-98. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.3.94-98
Authors’ contribution: Bezrukova D.A. – substantiation of the research concept, design of the research methodology, editing. Filipchuk A.V. – data collection, analysis of the received material, writing the text of the manuscript. Osmaeva Z.S. – data collection, analysis of the received material. Bezrukova D.D. – data collection, analysis of the received material. Ivannikova V.V. – designing research methodology, editing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: The retrospective design of the study did not require informed consent from patients for statistical processing of anonymized data for subsequent publication.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
Keywords
lytic cocktail
hyperthermia
emergency care
pediatrics
About the Authors
D.A. Bezrukova, Dr. Sci. (Med.), Professor, Head of the Department of Propaedeutics of Childhood Diseases, Outpatient and Emergency Pediatrics, Astrakhan State Medical University, Astrakhan, Russia; dina-bezrukova@mail.ru, ORCID: https://orcid.org/0000-0001-6819-5797Z.Sh. Osmaeva, 4th-year student, Faculty of Pediatrics, Astrakhan State Medical University, Astrakhan, Russia; zajka.osmaeva@mail.ru,
ORCID: https://orcid.org/0000-0003-0508-7654
A.V. Filipchuk, Teaching Assistant, Department of Propaedeutics of Childhood Diseases, Outpatient and Emergency Pediatrics, Astrakhan State Medical University, Astrakhan, Russia; filipchuk777797@yandex.ru, ORCID: https://orcid.org/0000-0003-1081-5687 (corresponding author)
D.D. Bezrukova, 4th year student of the Pediatric Faculty, Astrakhan State Medical University, Astrakhan, Russia; diana.bezrukova.2016@gmail.com, ORCID: https://orcid.org/0009-0005-4047-3042
V.V. Ivannikova, Pediatrician, Children’s City Polyclinic No. 1, Astrakhan, Russia; vik_fik_00@mail.ru, ORCID: https://orcid.org/0009-0006-6509-7503
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