Multiple organ failure in children after cardiac, urological, and abdominal surgeries: frequency, pattern, and risk factors (literature review)
Aripov O.A., Khaydarov K.I., Mamatkulov I.B., Khaydarov M.B.
This review aimed to examine current statistics, causes, and predisposing factors for the development of multiple organ failure (MOF) in children of different ages after cardiac, abdominal, and urinary tract surgery. A systematic analysis of the scientific literature (2010–2025) from leading global and Russian databases was conducted. The results show that MOF occurs in 15–35% of children after cardiac surgery, 8–22% after abdominal surgery, and 3–12% after urological procedures. The analysis revealed unique risk factors for each type of surgery and age-related characteristics of organ dysfunction. Multiple organ failure remains a significant postoperative complication in children, requiring a comprehensive approach to prevention and treatment that takes into account the specifics of the surgery and the patient’s age.
For citations: Aripov O.A., Khaydarov K.I., Mamatkulov I.B., Khaydarov M.B. Multiple organ failure in children after cardiac, urological, and abdominal surgeries: frequency, pattern, and risk factors (literature review). Pharmateca. 2026;33(3):64-69. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.3.64-69
Authors’ contribution: All authors made an equivalent contribution to the preparation of the publication.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Keywords
multiple organ failure
children
cardiac surgery
abdominal surgery
urology
risk factors
postoperative complications
About the Authors
O.A. Aripov, Head of the Department of Clinical Laboratory Diagnostics, Center for the Development of Professional Qualifications of Medical Workers, Tashkent, Republic of Uzbekistan; ORCID: https://orcid.org/0009-0000-6472-4604K.I. Khaydarov, Dr. Sci. (Med.), Associate Professor, Department of Pediatric Surgery, Urology, Pediatric Urology, Anesthesiology and Resuscitation, Pediatric Anesthesiology and Resuscitation, Tashkent State Medical University, Tashkent, Republic of Uzbekistan;
ORCID: https://orcid.org/0000-0002-1107-0528
I.B. Mamatkulov, Cand. Sci. (Med.), Associate Professor, Department of Pediatric Surgery, Urology, Pediatric Urology, Anesthesiology and Resuscitation, Pediatric Anesthesiology and Resuscitation, Tashkent State Medical University, Tashkent, Uzbekistan; mikhtiyor77@mail.ru,
ORCID: https://orcid.org/0000-0003-4053-4544 (corresponding author)
M.B. Khaydarov, Teaching Assistant, Department of Pediatric Surgery, Urology, Pediatric Urology, Anesthesiology and Resuscitation, Pediatric Anesthesiology and Resuscitation, Tashkent State Medical University, Tashkent, Uzbekistan; ORCID: https://orcid.org/0000-0002-1107-0528
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