Experience with the use of dupilumab in an adolescent with resistant eosinophilic esophagitis and transsyndromic endocrine and atopic comorbidity: a case report and literature review

Gorban V.V., Levin P.V., Gorban E.V., Duverger D.O., Zimmerman T.S.

Kuban State Medical University, Krasnodar, Russia

Background: The increasing incidence of eosinophilic esophagitis (EoE) in children, despite improvements in diagnostic methods, represents a serious problem. Therefore, the search for optimal treatment methods is particularly urgent. Biological therapy may prove highly effective and safe, especially in cases resistant to standard therapy.
Description of the clinical case: This article presents the experience of using dupilumab in a 15-year-old adolescent with EoE and bronchial asthma, who had been on long-term systemic glucocorticosteroid therapy without significant improvement. Progressive eosinophilic inflammation, fibrotic changes in the esophagus, malnutrition, and a significant deterioration in the patient’s quality of life prompted the administration of dupilumab, which resulted in clinical, endoscopic, and histological remission.
Conclusion: This clinical case demonstrates the potential of dupilumab as an effective treatment for severe, refractory forms of EoE in children with comorbidities.

For citations: Gorban V.V., Levin P.V., Gorban E.V., Duverger D.O., Zimmerman T.S. Experience with the use of dupilumab in an adolescent with resistant eosinophilic esophagitis and transsyndromic endocrine and atopic comorbidity: a case report and literature review. Pharmateca. 2026;33(3):128-133. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.3.128-133

Authors’ contribution: Gorban V.V. – writing and editing the text, analysis of literature. Levin P.V. – concept and editing of the text. Gorban E.V. – writing and editing the text. Zimmerman T.S. - concept and presentation of clinical data. Duverger D.O. – literary search, help with design.
All authors gave the final consent to the manuscript and agreed to be responsible for all aspects of work, vouching for their accuracy and impeccability.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

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About the Authors

Vitaly V. Gorban, Dr. Sci. (Med.), Head of the Department of Gastroenterology and Gastroenterology, Moscow. Department of Outpatient Therapy with a Course of General Medical Practice (Family Medicine), Kuban State Medical University, Krasnodar, Russia; gorbanvv@mail.ru, ORCID:
https://orcid.org/0000-0001-8665-6796 (corresponding author)
Pavel V. Levin, Assistant Professor, Department of Pediatrics No. 1, Kuban State Medical University, Krasnodar, Russia; ORCID:
https://orcid.org/0000-0003-4702-3093
Elena V. Gorban, Cand. Sci. (Med.), Associate Professor, Department of Outpatient Therapy with a Course of General Medical Practice (Family Medicine), Kuban State Medical University, Krasnodar, Russia; msgorban@mail.ru
Daria O. Duverger, Student, Kuban State Medical University, Krasnodar, Russia; dariaduverger@yandex.ru
Tatiana S. Zimmerman, Student, Kuban State Medical University, Krasnodar, Russia; dariaduverger@yandex.ru

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