Evaluation and efficacy of the tablet form of Alfazox in the treatment of patients with gastroesophageal reflux disease

Akhmedov V.A., Livzan M.A., Gaus O.V.

Omsk State Medical University, Omsk, Russia

Gastroesophageal reflux disease (GERD) has increasingly attracted the attention of practitioners of various specialties in recent years due to the presence of various disease phenotypes, including extraesophageal manifestations. We present 2 clinical cases of patients with GERD. A distinctive feature of the first phenotype was the absence of classical manifestations of GERD, and the predominance of the patient’s only extraesophageal manifestation in the form of recurrent pharyngitis. The second clinical case is presented in patients with combined esophageal and extraesophageal manifestations of GERD with erosive esophagitis and reflux-induced laryngitis. The therapy of patients consisted of a modification of nutrition and lifestyle, and drug therapy consisted in the first case of a combination of the prokinetic Itopride and the esophagoprotector Alfazox Tabs, and in the second case of a combination of PPIs esomeprazole with the esophagoprotector Alfazox Tabs. In both cases, it was possible to achieve clinical and endoscopic remission with a significant decrease in the total number of symptoms in patients tested using the RSI scores questionnaire. 

For citations: Akhmedov V.A., Livzan M.A., Gaus O.V. Evaluation and efficacy of the tablet form of Alfazox in the treatment of patients with gastroesophageal reflux disease. Pharmateca. 2026;33(6):17-21. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.6.17-21

Authors’ contribution: The authors contributed equally to all stages of the work and the preparation of the article.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.

Keywords

About the Authors

Vadim A. Akhmedov, Dr. Sci. (Med.), Professor, Head of the Department of Medical Rehabilitation, Omsk State Medical University, Omsk, Russia; v_akhmedov@mail.ru, ORCID: https://orcid.org/0000-0002-7603-8481, Scopus Author ID: 6603891660, eLibrary SPIN: 1678-6093
Maria A. Livzan, Dr. Sci. (Med.), Professor, Corr. Member of the RAS, Head of the Department of Faculty Therapy and Gastroenterology, Omsk State Medical University, Omsk, Russia; mlivzan@yandex.ru, ORCID: https://orcid.org/0000-0002-6581-7017, Scopus Author ID: 24341682600,
eLibrary SPIN: 1961-4082 (corresponding author)
Olga V. Gaus, Dr. Sci. (Med.), Professor at the Department of Faculty Therapy and Gastroenterology, Omsk State Medical University, Omsk, Russia; gaus_olga@bk.ru, ORCID: https://orcid.org/0000-0001-9370-4768, Scopus Author ID: 56598554900, eLibrary SPIN: 7116-8419

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