An epigenetic approach to correcting involutional skin changes

Kruglova L.S., Polonskaya A.S.

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia

The study of aging mechanisms has remained an important area of scientific research for many years. Currently, particular attention is being paid to epigenetic mechanisms of aging. Current knowledge of the epigenetic aspects of age-related skin changes opens up extensive opportunities for the development of therapeutic tools that target the cellular and molecular patterns of skin aging. Epicellin, a flavonoid from Ampelopsis grossedentata, exhibits antioxidant, anti-inflammatory, antibacterial, and antitumor activity. It reactivates youth genes and significantly eliminates signs of skin aging caused by epigenetic changes by inhibiting DNA methyltransferase 1, an enzyme that plays a key role in age-associated pathological DNA methylation.

For citations: Kruglova L.S., Polonskaya A.S. An epigenetic approach to correcting involutional skin changes. Pharmateca. 2025;32(10):33-38. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.10.33-38

Authors’ contribution: All authors confirm that their authorship complies with the international ICMJE criteria (all authors made significant contributions to the concept development, research and analysis, and preparation of the article, and read and approved the final version before publication). The major contributors were: L.S. Kruglova – literature review, writing, and editing the article. A.S. Polonskaya – collection and analysis of literary sources.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship. 
Additional information: Permissions for republication and licensing.

Keywords

About the Authors

L.S. Kruglova, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Rector, Head of the Department of Dermatovenereology and Cosmetology, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; kruglovals@mail.ru, ORCID: http://orcid.org/0000-0002-5044-5265 (corresponding author)
A.S. Polonskaya, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; dr.polonskaia@gmail.com, ORCID: https://orcid.org/0000-0001-6888-4760

Similar Articles