Effects of antidepressants in therapeutic practice

Matviyevskaya E.N., Bogochanov V.S., Shevchenko A.M.

Tver State Medical University, Tver, Russia

In recent years, medical practice has seen growing interest in antidepressants (ADs), not only as psychotropic agents but also as medications with a broad spectrum of systemic effects. This article examines the key actions of antidepressants of various pharmacological groups and their impact on the pathogenetic links of diseases of the bronchopulmonary, cardiovascular, digestive, urinary, nervous, endocrine, hematopoietic, connective tissue, and skin systems. Particular attention is paid to the use of antidepressants in comorbid conditions. Data on the positive and negative, as well as potentially positive and negative, effects of these medications in therapeutic practice are presented. A conclusion is drawn regarding the advisability of more widespread use of antidepressants as part of pathogenetic therapy, when indicated, taking into account the individual patient profile and potential risks.

For citations: Matviyevskaya E.N., Bogochanov V.S., Shevchenko A.M. Effects of antidepressants in therapeutic practice. Pharmateca. 2026;33(1):171-179. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.1.171-179

Authors’ contribution: E.N. Matvievskaya – study concept and design, scientific editing. V.S. Bogochanov and A.M. Shevchenko – data collection and processing. E.N. Matvievskaya, V.S. Bogochanov, and A.M. Shevchenko – writing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

Keywords

About the Authors

E.N. Matvievskaya, Cand. Sci. (Med.), Associate Professor, Department of Outpatient Therapy, Tver State Medical University, Tver, Russia; e.matvievskaya@list.ru, ORCID: https://orcid.org/0009-0006-6817-8077, eLibrary SPIN: 7590-9823 (corresponding author)
V.S. Bogochanov, 6th-year Student, Faculty of General Medicine, Tver State Medical University, Tver, Russia; ORCID: https://orcid.org/0000-0002-2989-8753, eLibrary SPIN: 6490-7436
A.M. Shevchenko, 6th-year Student, Faculty of General Medicine, Tver State Medical University, Tver, Russia; ORCID: https://orcid.org/0009-0008-5546-2073

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