Microbiome and depression: the impact of the microflora state on the treatment of depressive disorders

Dmitrievskaya M.I., Porfirova E.S., Tikhonenko P.A., Shchegortsova O.S.

Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, Crimean Federal University named after V.I. Vernadsky, Simferopol, Russia

It is well known that the human intestinal microflora can radically affect the state of health, both physical and mental. The microbiota is connected with the central nervous system via the «gut-brain» axis – a complex bidirectional communication system, including neural, endocrine and immune mechanisms. A number of studies have shown that people diagnosed with major depressive disorder also suffer from dysbiosis (decrease in Lactobacillus and Bifidobacterium, increase in Enterobacteriaceae), and a number of antidepressants can worsen this condition. Such disorders require appropriate correction, and the effect of the multi-strain probiotic not only on metabolic and intestinal disorders, but also on the course of depression is of interest. It is able to restore the balance of microflora, reduce inflammation and stimulate the synthesis of neuroactive substances (serotonin, dopamine, GABA), which makes its use promising in psychiat-ry, compared with traditional approaches focused exclusively on central mechanisms.

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About the Authors

Maria I. Dmitrievskaya, Associate Professor at the Department of Basic and Clinical Pharmacology, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, Crimean Federal University named after V.I. Vernadsky, Simferopol, Russia; m.dmitrievskaya@mail.ru, ORCID ID: https://orcid.org/0000-0001-5722-1726 (corresponding author)
Elina S. Porfirova, Student, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, Crimean Federal University named after V.I. Vernadsky, Simferopol, Russia; elina.porfirova@mail.ru, ORCID ID: https://orcid.org/0009-0008-5023-5680
Polina A. Tikhonenko, Student, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, Crimean Federal University named after V.I. Vernadsky, Simferopol, Russia; tihonenkopolina2@gmail.com, ORCID ID: https://orcid.org/0009-0003-3615-2065
Oksana S. Shchegortsova, Student, Order of the Red Banner of Labor Medical Institute named after S.I. Georgievsky, Crimean Federal University named after V.I. Vernadsky, Simferopol, Russia; oxana.shegortsova@yandex.ru, ORCID ID: https://orcid.org/0009-0000-7250-8514

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