Efficacy of Superlymph in preparation for in vitro fertilization in patients with thin endometrium
Dikke G.B., Sukhanov A.A., Pesotskaya A.V., Kukarskaya I.I., Shilova N.V.
Objective: Evaluation of the effectiveness of topical therapy using a complex of natural antimicrobial peptides and cytokines (Superlymph) in patients with thin endometrium (TE) and reproductive dysfunction prior to in vitro fertilization and embryo transfer (IVF).
Materials and methods: Ninety patients with TE and diagnosis N97.2: Female infertility of uterine origin (oocyte implantation defect) were included. Groups I (n=45) received Superlymph, Group II (n=45) received autologous platelet-rich plasma (PRP) injections into the endometrial submucosal layer, and Group III (n=45) included women with normal endometrial thickness (male factor infertility). Research methods included clinical, laboratory (smear microscopy and real-time PCR of vaginal contents), biochemical, functional (pelvic ultrasound, Doppler ultrasound), morphological, and immunohistochemical (IHC) tests (CD138 determination).
Results: After treatment, M-echo in the second phase of the cycle increased from 5.8 and 5.4 mm in Groups I and II, respectively, to 7.3 mm in both groups; sclerosis of the spiral arteries of the endometrium significantly decreased, and the endometrial structure corresponded to the day of the menstrual cycle; laboratory testing showed no local inflammation. The pregnancy rate in Group I was 42.2%, while in Group II it was 37.7%, with an absolute difference in rates of 4.5% in favor of Superlymph. The odds of pregnancy and live birth were comparable between the groups (OR=1.12, 95% CI: 0.67–1.86, p=0.83 and OR=1.23, 95% CI: 0.67–2.25, p=0.65, respectively). Pregnancy outcomes were also comparable and did not differ statistically significantly from the control group.
Conclusion: Therapy using the Superlymph complex in patients with TE and infertility before IVF is no less effective than PRP therapy.
For citations: Dikke G.B., Sukhanov A.A., Pesotskaya A.V., Kukarskaya I.I., Shilova N.V. Efficacy of Superlymph in preparation for in vitro fertilization in patients with thin endometrium. Pharmateca. 2026;33(4):187-198. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.4.187-198
Authors’ contribution: Dikke G.B. – development of the concept, design and program of the study, analysis of the results of statistical processing of clinical material and their interpretation, search for literary sources, writing fragments of the article and editing it after review. Sukhanov A.A. – collection of clinical material, formation of an electronic database, writing fragments of the article. Pesotskaya A.V. – analysis of the results of the morphological study, writing a fragment of the article. Kukarskaya I.I. – organization of the study at the clinical site, supervision during the study. Shilova N.V. – statistical analysis of the study results, writing fragments of the article.
Conflicts of interest: The authors report no conflicts of interest and guarantee that the article is the original work of the authors.
Funding: The research was carried out at our own expense. Publication of the article was supported by «Biotechpharm» LLC.
Ethical Approval: The study was approved by the Ethics Committee of the Tyumen State Medical University of the Ministry of Health of the Russian Federation (protocol No. 116 dated September 27, 2023).
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.
Keywords
endometrial hypoplasia
«thin endometrium»
infertility
in vitro fertilization
superlymph
autologous platelet-rich plasma
PRP therapy
About the Authors
Galina B. Dikke, Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology with a Course in Reproductive Medicine, F.I. Inozemtsev Academy of Medical Education, St. Petersburg, Russia; galadikke@yandex.ru, ORCID: https://orcid.org/0000-0001-9524-8962 (corresponding author)Anton A. Sukhanov, Dr. Sci. (Med.), Head of the Department of Gynecology, Perinatal Center; Associate Professor, Department of Obstetrics and Gynecology, Tyumen State Medical University, Tyumen, Russia; saa2505anton@yandex.ru, ORCID: https://orcid.org/0000-0001-9092-9136
Anastasia V. Pesotskaya, Head of the Pathology Laboratory with the Immunohistochemistry Department, Altai Regional Clinical Perinatal Center, Barnaul, Russia; pesokpesotskaya@yandex.ru, ORCID: https://orcid.org/0000-0002-4625-0916
Irina I. Kukarskaya, Dr. Sci. (Med.), Professor, Department of Obstetrics, Gynecology, and Resuscitation with the Course in Clinical Laboratory Diagnostics, Institute of Continuous Professional Development, Tyumen State Medical University; Chief Physician, Perinatal Center, Tyumen, Russia; Chief Specialist in Obstetrics and Gynecology, Healthcare Department of the Tyumen Region; ORCID: https://orcid.org/0000-0002-8275-3553
Natalya V. Shilova, Cand. Sci. (Med.), Associate Professor, Department of Industrial Pharmacy, National Research Nuclear University MEPhI, Moscow, Russia; nvshilova@gmail.com, ORCID: https://orcid.org/0000-0001-6734-0147
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