Combination of diffuse toxic goiter and connective tissue disease (clinical observation)
The relationship between thyroid diseases and various systemic connective tissue disorders has been known for a long time, including the association of systemic scleroderma and scleroderma-like fibrosing skin lesions with thyroid diseases. However, the literature mainly describes cases of a combination of connective tissue diseases with hypothyroidism against the background of chronic autoimmune thyroiditis. The authors describe a clinical case of associated course of diffuse toxic goiter complicated by endocrine ophthalmopathy and connective tissue disease lasting 14 years. The article discusses the difficulties of diagnosis and choice of treatment tactics for such a patient. A multidisciplinary approach to managing a patient with combined autoimmune pathology of the thyroid gland and connective tissue can increase the effectiveness of treatment and improve the long-term prognosis.L.A. Sharonova, S.V. Bulgakova, O.V. Kosareva, Yu.A. Dolgikh, P.Ya. Merzlova, E.V. Treneva, D.P. Kurmaev
Keywords
Graves’ disease
diffuse toxic goiter
thyrotoxicosis
connective tissue diseases
systemic scleroderma
adult scleroderma
About the Authors
Lyudmila A. Sharonova, Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; l.a.sharonova@samsmu.ru, ORCID: https://orcid.org/0000-0001-8827-4919 (corresponding author)Svetlana V. Bulgakova, Dr. Sci. (Med.), Associate Professor, Head of the Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; osteoporosis63@gmail.com, ORCID: https://orcid.org/0000-0003-0027-1786
Olga V. Kosareva, Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; o.v.kosareva@samsmu.ru, ORCID: https://orcid.org/0009-0006-4531-9682
Yulia A. Dolgikh, Cand. Sci. (Med.), Assistant Professor, Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; yu.a.dolgikh@samsmu.ru, ORCID: https://orcid.org/0000-0001-6678-6411
Polina Ya. Merzlova, Assistant, Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; p.ya.merzlova@samsmu.ru, ORCID: https://orcid.org/0009-0004-6243-6528
Ekaterina V. Treneva, Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; eka1006@yandex.ru, ORCID: https://orcid.org/0000-0003-0097-7252
Dmitry P. Kurmaev, Assistant, Department of Endocrinology and Geriatrics, Samara State Medical University, Samara, Russia; geriatry@mail.ru, ORCID: https://orcid.org/0000-0003-4114-5233
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