Rationale for the use of systemic antibiotics in the initial stages of treatment of severe acne

K.B. Olkhovskaya

Department of Skin and Sexually Transmitted Diseases, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia

Background. Treatment of severe acne is a difficult task in the daily practice of dermatovenerologists.
Objective. Determination of the effectiveness, tolerability and validity of prescribing systemic antibiotics in the early stages of treatment of patients with severe acne.
Methods. The present study scientifically validated the use of systemic antibiotics in the treatment of 52 patients with severe acne before prescribing isotretinoin.
Results. This method of patient management not only contributed to the high effectiveness of therapy, but also led to the formation of stable remission in the majority of subjects, a decrease in signs of systemic inflammatory reactions in the early stages of treatment, and most importantly, high assessment of treatment results by patients.
Conclusion. This observational study demonstrates the absolute validity of introducing systemic antibiotics into the treatment of patients with severe acne at the initial stages before prescribing systemic isotretinoin.

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About the Authors

Corresponding author: Kira B. Olkhovskaya, Cand. Sci. (Med.), Associate Professor at the Department of Skin and Sexually Transmitted Diseases, 
A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; olhovskaya_kira@mail.ru; ORCID: https://orcid.org/0000-0003-4920-5288; eLibrary SPIN: 9455-9482

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