Comorbidity of liver and biliary tract diseases

E.Yu. Plotnikova, L.G. Vologzhanina, A.Z. Azanov, A.S. Sukhikh

1) Kemerovo State Medical University, Kemerovo, Russia; 2) Perm State Medical University named after Academician E.A. Wagner, Perm, Russia; 3) “Gastrocenter” LLC, Perm, Russia; 4) Yurga District Hospital, Outpatient Department, Yurga, Russia

Biliary tract diseases are among the most common (10–20% among the adult population in developed countries) and costly diseases of the digestive system in the world. In addition to biliary tract pathology, chronic liver diseases are an important global public health problem. The incidence of gallstones in chronic liver diseases is usually high. The prevalence of biliary tract diseases may be associated with age, gender, etiology and severity of the disease in patients with chronic liver diseases. The authors of this article linked the epidemiology, mechanisms and strategies of early diagnosis and treatment of biliary pathology in patients with chronic liver diseases. There are still questions about at what stage the state of the biliary tract should be assessed and what correction should be carried out to avoid serious complications. Hymecromone is currently positioned only as a selective cholespasmolytic with a choleretic effect in case of dysfunction of the biliary tract, including spasm of the sphincter of Oddi, but without cholekinetic activity, which makes the use of hymecromone safe in cholelithiasis. However, among its pleiotropic effects, an antifibrotic effect in liver diseases is also described. The authors present a pharmacochemical comparative analysis of the original Gimecromone and its generics.

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About the Authors

Ekaterina Yu. Plotnikova, Dr. Sci. (Med.), Professor, Professor at the Department of Postgraduate Training and Nursing, Head of the Course of Clinical Gastroenterology, Kemerovo State Medical University, Kemerovo, Russia; e-mail: eka-pl@rambler.ru, ORCID: https://orcid.org/0000-0002-6150-1808 (corresponding author)
Ludmila G. Vologzhanina, Cand. Sci. (Med.), Associate Professor, Department of Faculty Therapy No. 1, Perm State Medical University named after Academician E.A. Wagner; Director of the Gastrocenter LLC, Perm, Russia; ludovica@mail.ru, ORCID: https://orcid.org/0000-0003-3105-4645
Artur Z. Azanov, Gastroenterologist, Outpatient Department, Yurga District Hospital, Yurga, Russia; artur_zakir@mail.ru, ORCID: https://orcid.org/0009-0005-0152-4222
Andrey S. Sukhikh, Cand. Sci. (Med.), Head of the Laboratory of Physicochemical Studies of Pharmacologically Active and Natural Compounds, Kemerovo State Medical University, Kemerovo, Russia; suhih_as@list.ru, ORCID: https://orcid.org/0000-0001-9300-5334

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