Clinical and pathogenetic patterns of rosacea development
Rosacea (RC) is a chronic facial dermatosis that affects 2 to 10% of the population and is more common in women after the third decade of life. RC has a significant burden on patients, as it has significant consequences for physical and mental health. Both neurovascular and immunological factors play an important role in the pathogenesis. Recurrent clinical symptoms of RC affect appearance, are irritating and negatively affect emotional health. Significant correlations are known between RC and neuropsychiatric diseases that can affect cognitive functions, including depression, dementia, anxiety disorders, and migraine. With a long course of the disease, purulent-septic complications, deterioration of vision, distortion of facial features, and formation of scars on the skin may appear. Modern methods of treating RC with neurogenic changes are limited and reduce satisfaction, patient confidence in therapy, and can also aggravate psychological stress. Early seeking of help and proper treatment will help reduce inflammation and stop the development of the disease. The article describes the pathogenetic features of the development of RC, reveals neurovascular changes and autonomic dysregulation. The relationship between RC and various concomitant mental disorders is described in detail, clinical features and types of the disease are considered. Clinical manifestations of neurogenic RC and its distinctive features in comparison with other subtypes of this dermatosis are given.Ayupova K.R., Yusupova L.A.
Keywords
rosacea
pathogenesis
clinical picture
mental disorders
neurogenic rosacea
reactive oxygen species
About the Authors
Kamila R. Ayupova, PhD Candidate, Department of Dermatovenereology and Cosmetology, Kazan State Medical Academy – Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russia; skinderma@rambler.ru, ORCID: https://orcid.org/0000-0002-2179-1214, eLibrary SPIN: 3811-5710 (corresponding author)Luiza A. Yusupova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology, Kazan State Medical
Academy – Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russia; yuluizadoc@hotmail.com, ORCID:
https://orcid.org/0000-0001-8937-2158, eLibrary SPIN: 5743-6872
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