Genetically engineered biological therapy of severe bronchial asthma with benralizumab

Trushina E.Yu., Kostina E.M., Tipikin V.A., Illarinov I.I., Orlova E.A., Turovskaya A.A.

1) Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; 2) Tambov State University named after G.R. Derzhavin, Tambov, Russia

Genetically engineered biological therapy (GEBT) of bronchial asthma (BA) is a modern method of treating severe forms of the disease that are uncontrolled by traditional pharmacotherapeutic approaches. Currently, six monoclonal antibody drugs for the treatment of severe bronchial asthma (anti-IgE – omalizumab), interleukin (IL)-5 antagonists (anti-IL-5 – mepolizumab, reslizumab) and its receptor (anti-IL-5Rα – benralizumab), as well as antibodies that selectively bind to the IL-4 and IL-13 receptor (anti-IL-4/13Rα - dupilumab) and tezepelumab, promoting the inhibition of thymic stromal lymphopoietin (TSLP) are registered in Russia.
A special group consists of patients with the eosinophilic phenotype of BA, characterized by a severe uncontrolled course and resistance to standard treatment regimens in accordance with the basic step therapy of the disease.
The article presents a clinical case of the effectiveness of GEBT using benralizumab as an example in a patient with severe uncontrolled bronchial asthma (eosinophilic phenotype).

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About the Authors

Elena Yu. Trushina, Cand. Sci. (Med.), Associate Professor, Department of Pulmonology and Phthisiology, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education (Penza), Associate Professor, Department of Hospital Therapy with a Course in Psychiatry, Institute of Medicine and Health Protection, Tambov State University named after G.R. Derzhavin, Tambov, Russia; trushina.lena@mail.ru; ORCID: https://orcid.org/0000-0001-5673-9195, eLibrarySPIN: 2164-6580 (corresponding author)
Elena M. Kostina, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; ORCID: https://orcid.org/000-0003-1797-8040
Valery A. Tipikin, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; ORCID: https://orcid.org/0009-0000-0990-4661
Ilya I. Illarionov, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; ORCID: https://orcid.org/0009-0008-0725-3242
Ekaterina A. Orlova, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; ORCID: https://orcid.org/0000-0003-1402-2940
Alina A. Turovskaya, Penza Institute for Advanced Medical Training – Branch Campus of the Russian Medical Academy of Continuous Professional Education, Penza, Russia; ORCID: https://orcid.org/0000-0002-5138-808X

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