Efficiency of human placenta extract as a subcutaneous injection in patients with uterine factor of infertility in ART programs

Kuzina S.V., Silantyeva E.S., Ovchinnikova M.M., Kutakova Yu.Yu.

GC Mother and Child. Lapino Clinical Hospital, Moscow, Russia

Background: The problem of infertility and implantation failures in ART programs is widespread in Russia and the world. The development of medicine and directly methods of assisted reproductive technologies (ART) have had a positive effect on the effectiveness of IVF programs, but the percentage of unsuccessful implantations remains high. The contribution of chronic endometritis as a uterine factor of infertility, reducing the percentage of pregnancy, is underestimated; there is no general concept for managing patients with this diagnosis.
Objective: Evaluation and justification of the effectiveness of complex treatment, including peptide therapy, in patients with chronic endometritis associated with ART programs.
Results: In this study, we substantiated the effectiveness of a comprehensive treatment algorithm for patients and described the contribution of human placenta extract to ART programs with infertility and a confirmed diagnosis of chronic endometritis.
Conclusion: The proposed treatment algorithm for patients with chronic endometritis associated with ART programs, including a combination of physiotherapy and peptide therapy with Melsmon, increases the pregnancy rate in cryopreservation cycles of euploid embryos to 73% and can be recommended for the treatment of uterine infertility.

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About the Authors

Stanislava V. Kuzina, Obstetrician-Gynecologist, GC Mother and Child, Lapino Clinical Hospital, Moscow, Russia; stasy83@bk.ru, ORCID:
https://orcid.org/0009-0006-9859-0003 (corresponding author)
E.S. Silantyeva, GC Mother and Child, Lapino Clinical Hospital, Moscow, Russia; https://orcid.org/0000-0002-7667-3231
M.M. Ovchinnikova, GC Mother and Child, Lapino Clinical Hospital, Moscow, Russia; https://orcid.org/0000-0002-3424-1721
Yu.Yu. Kutakova, GC Mother and Child, Lapino Clinical Hospital, Moscow, Russia; https://orcid.org/0000-0002-4273-4788

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