Successful achievement of remission in acne conglobata: a clinical case

Kucher I.E., Kabanov V.N., Pravdina O.V., Novikov Yu.A., Radul E.V.

1) Clinical Dermatovenereology Dispensary, Omsk, Russia; 2) Omsk State Medical University, Omsk, Russia

Background: Acne is a common skin condition affecting individuals of both sexes, primarily between the ages of 12 and 25. Acne conglobata is considered the most severe form of acne due to its pronounced inflammatory response, frequent development of persistent cosmetic defects, adverse psychosocial consequences, and resistance to treatment. 
Description of the clinical case: Clinical case of acne conglobata (nodularis) in a male patient, born in 2005, with no signs of somatic pathology, is described. Outpatient treatment with isotretinoin was administered for 18 months (cumulative dose of 172 mg/kg body weight). Initially, reduced daily doses of isotretinoin were used in combination with prednisolone and antibacterial agents. This resulted in stable remission. The patient was declared fit for military service without restrictions.
Conclusion: Severe acne can lead to the formation of persistent scarring not only directly but also due to the development of purulent complications requiring surgical intervention. Achieving stable remission may require a more cautious initiation of isotretinoin therapy, as well as an increased treatment duration and effective cumulative dose compared to standard treatments. 

For citations: Kucher I.E., Kabanov V.N., Pravdina O.V., Novikov Yu.A., Radul E.V. Successful achievement of remission in acne conglobata: a clinical case. Pharmateca. 2025;32(10):143-147. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.10.143-147

Authors’ contribution: Collection and processing of materials – I.E. Kucher, V.N. Kabanov. Writing of the text – V.N. Kabanov. Editing – Yu.A. Novikov, O.V. Pravdina, E.V. Radul.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: The patient provided an informed consent for the publication of their data.

Keywords

About the Authors

Irina E. Kucher, Dermatovenereologist, Outpatient Department No. 4, Clinical Dermatovenereology Dispensary, Omsk, Russia; diamondkdd@mail.ru; ORCID: https://orcid.org/0009-0009-3900-3851 (corresponding author)
Vladislav N. Kabanov, Dermatovenereologist, Head of Outpatient Department No. 4, Clinical Dermatovenereology Dispensary, Omsk, Russia; ORCID: https://orcid.org/0009-0009-4895-0092
Olga V. Pravdina, Dermatovenereologist, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Omsk State Medical University, Omsk, Russia; ORCID: https://orcid.org/0000-0002-1804-6248
Yuri A. Novikov, Dermatovenereologist, Dr. Sci. (Med.), Associate Professor, Head of the Department of Dermatovenereology and Cosmetology, Omsk State Medical University; Chief Physician, Clinical Dermatovenereology Dispensary, Omsk, Russia; ORCID: https://orcid.org/0000-0003-0391-5372
Elena V. Radul, Dermatovenereologist, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Omsk State Medical University, Omsk, Russia; ORCID: https://orcid.org/0000-0002-9395-9792

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