Modern approaches to the diagnosis and treatment of small intestinal bacterial overgrowth syndrome
Mubarakshina O.A., Dronova Yu.M., Chernov S.Yu., Zhdanova O.A.
Small intestinal bacterial overgrowth syndrome (SIBOS) is a clinical and microbiological syndrome characterized by changes in the abundance and composition of the small intestinal microbiota, gastrointestinal symptoms (bloating, abdominal pain, diarrhea, or constipation), malabsorption, and nutritional deficiency in severe cases. Modern diagnostics are based on an assessment of the clinical manifestations of the disease, consideration of risk factors, and laboratory results, such as a hydrogen-methane breath test and small intestinal aspirate culture. Treatment of SIBOS includes intestinal microbial decontamination, restoration of normal microflora, elimination of nutritional deficiencies, and correction of risk factors for this condition. This review systematizes modern algorithms for the diagnosis and treatment of small intestinal bacterial overgrowth syndromw (SIBOS), based on the principles of evidence-based medicine. It presents data on the role of probiotics and synbiotics in restoring the intestinal microbiome and preventing relapses of dysbiotic disorders.
For citations: Mubarakshina O.A., Dronova Yu.M., Chernov S.Yu., Zhdanova O.A. Modern approaches to the diagnosis and treatment of small intestinal bacterial overgrowth syndrome. Pharmateca. 2026;33(4):51-60. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.4.51-60
Authors’ contribution: Concept of the article – O.A. Mubarakshina, O.A. Zhdanova. Collection and processing of material – S.Yu. Chernov, Yu.M. Dronova, O.A. Mubarakshina. Text writing – O.A. Mubarakshina, Yu.M. Dronova. Scientific editing – O.A. Zhdanova.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
About the Authors
Olga A. Mubarakshina, Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; mubarakshina@mail.ru, ORCID: https://orcid.org/0000-0001-6799-6322 (corresponding author)Yulia Mikhailovna Dronova, Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; y.dronova@yandex.ru, ORCID: https://orcid.org/0000-0003-4513-091X
Sergey Yu. Chernov, Cand. Sci. (Med.), Associate Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; sergeych6868@mail.ru, ORCID: https://orcid.org/0009-0002-8900-7745
Olga A. Zhdanova, Dr. Sci. (Med.), Associate Professor, Professor, Department of Clinical Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russia; olga.vr9@yandex.ru, ORCID: https://orcid.org/0000-0002-3917-0395
