A case of onychomycosis caused by the pathogen Trichophyton verrucosum in a patient with concomitant dermatological pathology
Chasnyk A.S., Pozdnyakova O.N., Nemchaninova O.B., Fomenko N.V., Kalymbetova T.V., Shipilova N.A., Sergeeva I.G.
Background. Nail pathologies which manifest with similar clinical signs are a common clinical situation in the practice of a dermatovenerologist. The imperfection of laboratory methods for research on fungal infections, the presence of combined lesions of the nail plates with other skin changes in the patient, as well as the growth of atypical pathogens in the etiological structure of onychomycosis complicate diagnosis.
Description of a clinical case. The article presents a clinical observation of a patient with a long-term course of nail mycosis caused by Trichophyton verrucosum, combined with changes in the skin of the face, scalp and perianal area. Repeated microscopic examinations of scrapings from the nail plates showed the presence of single yeast cells and spores, while external etiotropic therapy did not lead to improvement. PCR diagnostics for fungi gave a positive result (Fungi 32.7), but the pathogen was not identified. Subsequent cultural research gave an increase in colonies of the fungus T. verrucosum.
Conclusion. The clinical case demonstrates the need for a personalized approach to patients with long-term dermatoses and reflects the pathomorphosis in the course of skin diseases, including fungal etiology. To finally diagnose nail mycosis caused by a zooanthropophilic pathogen, our patient needed a combination of several laboratory research methods.
For citations: Chasnyk A.S., Pozdnyakova O.N., Nemchaninova O.B., Fomenko N.V., Kalymbetova T.V., Shipilova N.A., Sergeeva I.G. A case of onychomycosis caused by the pathogen Trichophyton verrucosum in a patient with concomitant dermatological pathology. Pharmateca. 2025;32(9):95-100. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.9.95-100
Authors’ contribution: Study concept and design – I.G. Sergeeva. Material collection and processing – A.S. Chasnyk, N.V. Fomenko, T.V. Kalymbetova, N.A. Shipilova. Text writing – A.S. Chasnyk, I.G. Sergeeva, O.N. Pozdnyakova. Editing – I.G. Sergeeva, O.B. Nemchaninova.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: All materials analyzed by the authors in the article, including photographs, are provided with the oral consent of the patient. Signed informed consent for the publication of personal medical information is missing.
Keywords
onychomycosis
Trichophyton verrucosum
laboratory diagnostics of fungal infections
microscopy
culture
PCR
About the Authors
Anna S. Chasnyk, Teaching Assistant, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; a.chasnyk@alumni.nsu.ru, ORCID: https://orcid.org/0009-0002-3663-1827, eLibrary SPIN: 3021-1059, Scopus Author ID: 59493909000 (corresponding author)Olga N. Pozdnyakova, Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; pozdnyakova.o.n@mail.ru, ORCID: https://orcid.org/0000-0003-1389-1001, eLibrary SPIN: 7800-7403
Olga B. Nemchaninova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology, Novosibirsk State Medical University, Novosibirsk, Russia; obnemchaninova@mail.ru, ORCID: https://orcid.org/0000-0002-5961-6980, eLibrary SPIN: 5658-9359
Natalia V. Fomenko, Cand. Sci. (Biol.), Senior Researcher, PCR Laboratory, AO Vector-Best, Novosibirsk, Russia; fomenkon@vector-best.ru, ORCID: https://orcid.org/0000-0001-6437-8959
Tatyana V. Kalymbetova, Cand. Sci. (Biol.), Researcher, PCR Laboratory, AO Vector-Best, Novosibirsk, Russia; kalymbetova@vector-best.ru, ORCID: https://orcid.org/0000-0002-8648-3714
Natalia A. Shipilova, Teaching Assistant, Department of Fundamental Medicine, Novosibirsk National Research State University, Novosibirsk, Russia; ORCID: https://orcid.org/0000-0002-7842-4423
Irina G. Sergeeva, Dr. Sci. (Med.), Professor, Department of Fundamental Medicine, V. Zelman Institute of Medicine and Psychology, Director, Center for Postgraduate Medical Education, Novosibirsk National Research State University, Novosibirsk, Russia; i_g_sergeeva@mail.ru, ORCID:
https://orcid.org/0000-0003-1748-8957, eLibrary SPIN: 4766-0410, Scopus Author ID: 57044473200
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