The role of human herpesvirus infections in the pathogenesis of immune-inflammatory dermatoses. Review article, part I

Evdokimov E.Yu., Svechnikova E.V., Domonova E.A., Ponezheva L.O., Rzhevskaya E.V.

1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia, Moscow, Russia; 2) Russian Biotechnology University (ROSBIOTECH), Department of Skin and Venereal Diseases with a Course in Cosmetology, Moscow, Russia; 3) City Polyclinic No. 180, Moscow Healthcare Department, Moscow, Russia; 4) Polyclinic No. 1 of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia

Human herpes viruses, being among the oldest pathogens, pose a significant health problem. Their unique ability to affect various organs and systems, as well as persist in the body, determines the chronic nature of the infection. Viruses most often enter through damaged skin and mucous membranes, triggering a cascade of immune responses, beginning with innate immunity in the skin and extending to other parts of the immune system as the virus replicates. the differentiated Immune response in herpes simplex virus monoinfection compared to coinfections caused by multiple herpesvirus types is of particular interest.
This review analyzes the relationship between latency and persistence of human herpes viruses and immune response characteristics in patients with inflammatory dermatoses that worsen with recurrent herpesvirus infections. Particular attention is paid to the role of herpes simplex virus types 1 and 2 in modulating immune responses and inflammatory processes. The article demonstrates that recurrences of herpesvirus infections and exacerbations of inflammatory dermatoses may be linked to common regulatory pathways of the immune response. These findings highlight the need for further research to develop new therapeutic approaches for the treatment of these interrelated pathologies.

For citations: Evdokimov E.Yu., Svechnikova E.V., Domonova E.A., Ponezheva L.O., Rzhevskaya E.V. The role of human herpesvirus infections in the pathogenesis of immune-inflammatory dermatoses. Review article, part I. Pharmateca. 2026;33(4):117-126. (In Russ.). DOI: 
https://dx.doi.org/10.18565/pharmateca.2026.4.117-126

Authors’ contribution: Е.Ю. Евдокимов – анализ имеющихся данных по герпесвирусным инфекциям, написание статьи. Е.В. Свечникова – редактирование и оформление статьи, внесение правок. Э.А. Домонова – написание блока статьи связанного с этиологией и эпидемиологиейгерпесирусов человека. Л.О. Понежева – написание блока статьи связанного с иммунологией герпесирусов человека. Е.В. Ржевская - редактирование и оформление статьи.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

Keywords

About the Authors

Evgeny Yu. Evdokimov, Dr. Sci. (Med.), Leading Researcher, Clinical Department of Infec-tious Pathology, Central Research Institute of Epidemiology, Russian Federal Service for Sur-veillance on Consumer Rights Protection and Human Well-Being; Dermatovenerologist, Poly-clinic No. 1 of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; ORCID: https://orcid.org/0000-0003-2694-8900
Elena V. Svechnikova, Dr. Sci. (Med.), Professor, Department of Skin and Venereal Diseases with a Course in Cosmetology, Russian Biotechnological University (ROSBIOTEKH), De-partment of Skin and Venereal Diseases with a Course in Cosmetology, Moscow; Head of the Department of Dermatovenereology and Cosmetology, Polyclinic No. 1 of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; elene-elene@bk.ru, ORCID: https://orcid.org/0000-0003-2694-8900 (corresponding author)
Elvira A. Domonova, Dr. Sci. (Med.), Head of the Department of Dermatovenereology and Cosmetology, Polyclinic No. 1 of the Administrative Directorate of the President of the Rus-sian Federation, Moscow, Russia; Laboratory of Molecular Diagnostics and Epidemiology of Opportunistic Infections, Department of Molecular Diagnostics and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; ORCID: http://orcid.org/0000-0001-8262-3938
Liana O. Ponezheva, Cand. Sci. (Med.), Allergist-Immunologist, City Polyclinic No. 180, Moscow Healthcare Department, Russia; ORCID:
https://orcid.org/0000-0001-9459-8143
Elena V. Rzhevskaya, Cand. Sci. (Med.), Chief Physician, Polyclinic No. 1 of the Administra-tive Directorate of the President of the Russian Federation, Moscow, Russia; ORCID: https://orcid.org/0000-0001-7194-8219