Retrospective analysis of non-hormonal treatment of stress-associated menstrual cycle disorders

Sokolova T.M., Makarov K.Yu., Kuleshov V.M., Kiseleva T.V.

Novosibirsk State Medical University, Novosibirsk, Russia

Objective: Retrospective analysis of the efficacy and safety of Mabelle Cycle for the treatment of stress-associated menstrual cycle disorders in real-world clinical practice.
Materials and methods: A retrospective analysis of the medical records of 40 patients with stress-associated menstrual cycle disorders (according to the International Classification of Diseases, 10th Revision: N91.1 Secondary amenorrhea, N91.4 Secondary oligomenorrhea). Participants received Mabelle Cycle (active ingredients: red clover extract, vitex chasteberry fruit extract, angelica chinensis root extract, griffonia simplicifolia seed extract, D,L-phenylalanine, and iron) for 6 months, taking 2 tablets once daily. Efficacy was assessed by menstrual cycle restoration. Safety and satisfaction with the use of this herbal complex were also assessed.
Study design: A retrospective observational study using patient medical records was conducted.
Results: An improvement in a number of clinical indicators was noted while taking Mabelle Cycle. 85.0% of patients reported a normal menstrual cycle after treatment, compared with 0% before treatment (p<0.001). At the same time, no statistically significant differences were found for a number of indicators: the frequency of amenorrhea decreased from 10.0 to 0% (p=0.125), oligomenorrhea – from 90.0 to 15.0% (p<0.001), dysmenorrhea – from 30.0 to 5.0% (p=0.002). A decrease in the frequency of anovulation was also noted from 100.0 to 67.5% (p<0.001). A decrease in psychoemotional manifestations was noted: the frequency of mood lability decreased from 67.5 to 7.5% (p<0.001), tearfulness – from 10.0 to 2.5% (p=0.250), aggressiveness – from 17.5 to 5.0% (p=0.062).
Conclusion: The non-hormonal complex Mabelle Cycle is characterized by proven efficacy and safety in the correction of stress-associated menstrual cycle disorders in women of reproductive age. High patient compliance is attributable to the combination of clinical efficacy with exceptional safety, good tolerability, and ease of use.

For citations: Sokolova T.M., Makarov K.Yu., Kuleshov V.M., Kiseleva T.V. Retrospective analysis of non-hormonal treatment of stress-associated menstrual cycle disorders. Pharmateca. 2026;33(4):179-186. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.4.179-186

Authors’ contribution: Sokolova T.M. – study concept and design, collection and processing of materials. K.Yu. Makarov, V.M. Kuleshov, T.V. Kiseleva – editing, statistical processing of materials, writing the text.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: Informed consent of the patient/legal representative for the use of information from medical records for the purposes of this study was not required.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.

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About the Authors

Tatyana M. Sokolova, Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Novosibirsk, Russia; tatyana3965@mail.ru, ORCID: https://orcid.org/0000-0003-3435-3536 (corresponding author)
Konstantin Yu. Makarov, Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Novosibirsk, Russia; fdpngma@mail, ORCID: https://orcid.org/0000-0003-3574-6382
Tatyana V. Kiseleva, Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Novosibirsk, Russia; kis_tv98@mail.ru, ORCID: https://orcid.org/0000-0002-4378-7945
Vitaly M. Kuleshov, Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology, Novosibirsk State Medical University, Novosibirsk, Russia, kuleshov_vm@mail.ru, ORCID: https://orcid.org/0000-0003-3304-1581

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