A rare case of onset of Crohn’s disease in a child presenting with exudative enteropathy. Clinical case

Koshurnikova A.S., Osmanov I.M., Radchenko E.R., Dmitrieva Yu.A., Mulina Yu.G., Epifanova E.I., Zakharova I.N.

1) Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia; 2) Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Differential diagnosis of Crohn’s disease and exudative enteropathy in young children is based on a comprehensive approach that includes analysis of clinical symptoms, medical history, and laboratory and instrumental examination methods [1]. If exudative enteropathy is suspected, causes of hypoproteinemia such as malnutrition, impaired protein synthesis or loss due to diseases of other organs – kidneys, liver or skin, protein loss due to inflammatory bowel disease – should be excluded [2]. The literature describes cases of secondary lymphangiectasia in Crohn’s disease in children [3], as well as in various infectious intestinal diseases – giardiasis, shigellosis, rotavirus gastroenteritis [4, 5]. This article presents an atypical clinical case of Crohn’s disease in a 6-year-old child with clinical and endoscopic manifestations of exudative enteropathy.

For citations: Koshurnikova A.S., Osmanov I.M., Radchenko E.R., Dmitrieva Yu.A., Mulina Yu.G., Epifanova E.I., Zakharova I.N. A rare case of onset of Crohn’s disease in a child presenting with exudative enteropathy. Clinical case. Клинический случай. Pharmateca. 2026;33(3):121-127. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.3.121-127

Acknowledgements: The article was published as part of a grant for the implementation of a scientific and practical project in the field of medicine, agreement No. 1209-11/25, funded by a grant from the Moscow Government. «Frequency, risk factors, clinical and pathomorphological, endoscopic, morphological variants and the tactics of observation in the current course of colitis in children using an extended study of hemostasis and a new method of liquid biopsy and high-throughput sequencing».
Authors’ contribution: The concept of the article – I.M. Osmanov, I.N. Zakharova, A.S. Koshurnikova. The concept and design of the study – A.S. Koshurnikova, I.N. Zakharova. Text writing – A.S. Koshurnikova. Collection and processing of the material – A.S. Koshurnikova, Yu.G. Mulina, Yu.A. Dmitrieva, E.R. Radchenko, E.I. Epifanova. Literature review – A.S. Koshurnikova. Material analysis – A.S. Koshurnikova. Final version of the article approval – I.N. Zakharova, I.M. Osmanov.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

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About the Authors

Anastasia S. Koshurnikova, Cand. Sci. (Med.), Head of the Endoscopy Department, Endoscopist, Moscow Doctor, Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia; saller03@mail.ru, ORCID: https://orcid.org/0000-0002-2306-9743 (corresponding author)
Ismail M. Osmanov, Dr. Sci. (Med.), Professor, Chief Pediatrician, Moscow Healthcare Department, Chief Physician, Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia; OsmanovIM@zdrav.mos.ru, ORCID: https://orcid.org/0000-0003-3181-9601
Elena R. Radchenko, Gastroenterologist, Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia, elen.radchenko@list.ru, ORCID:
https://orcid.org/0000-0001-5717-7171
Yulia A. Dmitrieva, Cand. Sci. (Med.), Head of the Gastrocenter, Gastroenterologist, Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow; Associate Professor, Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; jadmitrieva@mail.ru, ORCID: https://orcid.org/0000-0003-0668-7336
Yulia G. Mulina, Endoscopist, Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia; Mulina-1992@mail.ru, ORCID:
https://orcid.org/0009-0007-0506-3683
Elena I. Epifanova, Pathologist, Z.A. Bashlyaeva Children’s City Clinical Hospital, Moscow, Russia; elena26.09.86@mail.ru, ORCID:
https://orcid.org/0000-0003-3795-3203
Irina N. Zakharova, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Pediatrics named after G.N. Speransky, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; zakharova-rmapo@yandex.ru, ORCID:
https://orcid.org/0000-0003-4200-4598

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