The problem of drug-induced hepatotoxicity in oncology practice and methods for its correction

Skvortsov V.V., Kolomytsev V.V., Goryunova L.V.

Volgograd State Medical University, Volgograd, Russia

Drug-induced liver injury (DILI) is a serious problem in oncology practice due to the low selectivity of anticancer drugs and their metabolites. Improved survival rates for cancer patients and the expansion of the arsenal of chemotherapeutic agents, including targeted agents and immunotherapy, are contributing to the increasing prevalence of DILI, requiring effective approaches to prevention and correction. This review analyzes the mechanisms of chemotherapeutic agent hepatotoxicity, classification, and diagnosis of DILI.
Patient management includes biochemical monitoring, chemotherapeutic dose reduction, and the use of hepatoprotectors. IIt has been shown that among modern approaches to the correction of DILI, an important place is occupied by the use of a multicomponent drug (Remaxol®, INN: Inosine + Meglumine + Methionine + Nicotinamide + Succinic acid). This fixed combination provides a comprehensive pathogenetic effect, including correction of mitochondrial dysfunction, reduction of oxidative stress, stimulation of hepatocyte regeneration, and enhancement of detoxification processes. Clinical trial results demonstrate the efficacy of this preparation for both the prevention and treatment of DILI in cancer patients receiving polychemotherapy.

For citations: Skvortsov V.V., Kolomytsev V.V., Goryunova L.V. The problem of drug-induced hepatotoxicity in oncology practice and methods for its correction. Pharmateca. 2025;32(9):119-125. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.9.119-125

Authors’ contribution: Study concept and design – V.V. Skvortsov. Data collection and processing – V.V. Kolomytsev, L.V. Goryunova. Writing – V.V. Kolomytsev. Editing – V.V. Skvortsov, L.V. Goryunova.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

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About the Authors

Vsevolod V. Skvortsov, Dr. Sci. (Med.), Professor, Department of Internal Medicine, Volgograd State Medical University, Volgograd, Russia; vskvortsov1@ya.ru, ORCID: https://orcid.org/0000-0002-2164-3537 (corresponding author)
Viktor V. Kolomytsev, Student, Volgograd State Medical University, Volgograd, Russia; eRST142@yandex.ru
Lidiya V. Goryunova, Student, Volgograd State Medical University, Volgograd, Russia; Lidiagor200@mail.ru

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