Experience with the combined use of phototherapy and local ozone therapy in patients with rosacea

Pershina K.S., Bitkina O.A., Kosheleva I.V., Bitkina E.V.

1) Privolzhsky Research Medical University, Nizhny Novgorod, Russia; 2) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 3) Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russia

Background: This article examines the dynamics of facial skin functional parameters using the Multiskin diagnostic system.
Objective: Comparison of the effectiveness of phototherapy (PT) as a single-method physiotherapy treatment and the combined use of laser radiation and local ozone therapy in patients with rosacea.
Materials and methods: A primary prospective, non-randomized study was conducted. Forty-four women were included in the study. PT group consisted of 34 patients, while 10 patients received combined PT and topical ozone therapy (O3 group).
Results: The results of the study confirm the efficacy of both PT using the Candela Nordlys system and its combination with topical ozone therapy (O3) in patients with rosacea. Although both methods provided clinical improvement (regression of erythema, reduction in the number of papules and telangiectasias, and improvement in skin texture), each demonstrated advantages in specific areas of correction of functional skin parameters.
Conclusion: PT is more effective for patients with rosacea who have a predominantly vascular component and pronounced erythema, while PT combined with O3 is more appropriate for patients with dry skin, decreased elasticity, and a tendency toward post-inflammatory pigmentation. This differentiated approach allows not only to achieve clinical improvement but also to individualize therapy depending on the underlying pathogenetic mechanisms and the patient’s cosmetic expectations.

For citations: Pershina K.S., Bitkina O.A., Kosheleva I.V., Bitkina E.V. Experience with the combined use of phototherapy and local ozone therapy in patients with rosacea. Pharmateca. 2025;32(10):129-136. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.10.129-136

Authors’ contribution: The concept and design of the article – K.S. Pershina, O.A. Bitkina, I.V. Kosheleva, E.V. Bitkina. Writing – K.S. Pershina, O.A. Bitkina. Editing – K.S. Pershina, O.A. Bitkina, I.V. Kosheleva, E.V. Bitkina.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Ethical Approval: The study was approved by the Meeting of the Ethics Committee of Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation on June 7, 2024.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.
Authors’ Data Sharing Statement: The data supporting the findings of this study are available upon request from the corresponding author after approval from the principal investigator.

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About the Authors

K.S. Pershina, Postgraduate Student, Department of Skin and Venereal Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia; kris.tina1300@mail.ru, ORCID: https://orcid.org/0009-0003-4362-9618, elibrary SPIN: 5989-4477 (corresponding author)
O.A. Bitkina, Privolzhsky Research Medical University, Nizhny Novgorod, Russia; ORCID: https://orcid.org/0000-0003-4993-3269
I.V. Kosheleva, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; ORCID: https://orcid.org/0000-0003-2767-3021
E.V. Bitkina, Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russia; ORCID: https://orcid.org/0009-0009-3175-0836

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