Experience with the use of a preparation containing polyhexanide and betaine in the treatment of secondary infected dermatoses

Kruglova L.S., Gryazeva N.V., Tamrazova A.V.

Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia

This article examines the problem of secondary infection in atopic dermatitis (AD), caused by impaired skin barrier function and dysbiosis, with a predominance of Staphylococcus aureus. The role of bacterial, fungal, and viral infections in aggravating the disease is emphasized. Three clinical cases demonstrate the effectiveness of a gel containing polyhexanide and betaine. Application of the gel ensured gentle cleansing of crusts and biofilm, exerted an antimicrobial effect, and created optimal conditions for regeneration, significantly increasing the effectiveness of subsequent anti-inflammatory therapy and achieving rapid relief of infection symptoms.

For citations: Kruglova L.S., Gryazeva N.V., Tamrazova A.V. Experience with the use of a preparation containing polyhexanide and betaine in the treatment of secondary infected dermatoses. Pharmateca. 2025;32(10):45-52. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.10.45-52

Authors’ contribution: All authors confirm that their authorship complies with the international ICMJE criteria (all authors made a significant contribution to the concept development, research and analysis, and preparation of the article, and read and approved the final version before publication). The main contributors were: L.S. Kruglova – literature review, collection and analysis of literature sources, writing the text, and editing the article. N.V. Gryazeva – patient supervision, determination of diagnosis and treatment tactics, and patient photography. A.V. Tamrazova – collection of literature sources and proofreading the article.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: The patients provided an informed consent for the publication of their data.

Keywords

About the Authors

Larisa S. Kruglova, Dr. Sci. (Med.), Professor, Head of the Department of Dermatovenereology and Cosmetology, Rector, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; kruglovals@mail.ru, ORCID: https://orcid.org/0000-0002-5044-5265 (corresponding author)
Natalya V. Gryazeva, Dr. Sci. (Med.), Professor, Department of Dermatovenereology and Cosmetology, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; tynrik@yandex.ru, ORCID: https://orcid.org/0000-0003-3437-5233
Anait V. Tamrazova, Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology and Cosmetology, Central State Medical Academy of the Administrative Directorate of the President of the Russian Federation, Moscow, Russia; anattamrazova@gmail.com, ORCID: https://orcid.org/0000-0002-4672-697X