Cardiotoxicity of anticancer chemotherapy in patients at cardiovascular risk

Shambatov M.A., Izmozherova N.V., Chubatov A.V., Smolenskaya O.G., Vedenskaya S.S., Petrovskikh A.A., Shesterova Ya.A.

Ural State Medical University, Yekaterinburg, Russia

Background: Modern advances in cancer treatment have significantly increased patient survival; however, side effects of therapy, particularly cardiotoxicity, are becoming a serious problem. The incidence of cancer increases with age, and patients often have pre-existing cardiovascular disease or risk factors for its development. This necessitates the study of the cardiotoxicity of anticancer therapy, as well as the search for an approach to the diagnosis, monitoring, and treatment of cardiovascular complications.
Objective: Review of the literature and identification of the most common types of cardiotoxicity associated with modern anticancer drugs in patients at high cardiovascular risk, discussion of specific diagnostic, monitoring, and treatment options for adverse cardiovascular events.
Methods: From February to April 2025, a search of the PubMed, Google Scholar, and Cyberleninka databases was conducted using the following keywords: anticancer therapy cardiotoxicity, CTRCVD, high cardiovascular risk, cardiotoxicity diagnosis and treatment, and CTRCD diagnosis and treatment.
Results: A literature review identified the most cardiotoxic anticancer drug classes, with a description of the mechanism for the development of this side effect for each. Current methods for assessing the risk of cardiovascular toxicity in cancer patients, as well as approaches to diagnosis, monitoring, and drug prevention of cardiotoxicity in high-risk patients, were also presented.
Conclusion: Cardiologists and oncologists should pay attention to the risks of cardiotoxicity of anticancer therapy and ensure individualization of therapy after a thorough assessment of the benefits of a specific anticancer agent and the possible risk of cardiotoxicity.

For citations: Shambatov M.A., Izmozherova N.V., Chubatov A.V., Smolenskaya O.G., Vedenskaya S.S., Petrovskikh A.A., Shesterova Ya.A. Cardiotoxicity of anticancer chemotherapy in patients at cardiovascular risk. Pharmateca. 2026;33(1):158-170. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.1.158-170

Authors’ contribution: Shambatov M.A. – study concept, discussion of results, final editing. Izmozherova N.V. – study concept, discussion of results, final editing.Chubatov A.V. – source search and selection, discussion of results, article writing. Smolenskaya O.G. – discussion of results, final editing. Vedenskaya S.S. – discussion of results, final editing. Petrovskikh A.A. – source search and selection, discussion of results, article writing, final editing. Shesterova Ya.A. – search and selection of sources, discussion of results, writing the article, final editing.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

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About the Authors

Muraz A. O. Shambatov, Cand. Sci. (Med.), Associate Professor, Department of Pharmacology and Clinical Pharmacology, Ural State Medical University, Yekaterinburg, Russia; shambatovma@gmail.com, ORCID: https://orcid.org/0000-0001-7312-415X, eLibrary SPIN: 6693-5347
Nadezhda V. Izmozherova, Dr. Sci. (Med.), Professor, Head of the Department of Pharmacology and Clinical Pharmacology, Ural State Medical University; Chief Clinical Pharmacologist, Ministry of Health of the Sverdlovsk Region, Yekaterinburg, Russia; nadezhda_izm@mail.ru, ORCID: https://orcid.org/0000-0001-7826-9657, eLibrary SPIN: 4738-3269 (corresponding author)
Aleksey V. Chubatov, Postgraduate Student, Department of Faculty Therapy, Allergology, and Immunology, Ural State Medical University, Yekaterinburg, Russia; a.chubatov88@mail.ru, ORCID: https://orcid.org/0009-0009-5347-6110, eLibrary SPIN: 4519-0061
Olga G. Smolenskaya, Dr. Sci. (Med.), Professor, Head of the Department of Faculty Therapy, Allergology, and Immunology, Ural State Medical University, Yekaterinburg, Russia; o.smolenskaya@mail.ru, ORCID: https://orcid.org/0000-0002-0705-6651, eLibrary SPIN 5443-9382
Svetlana S. Vedenskaya, Cand. Sci. (Med.), Associate Professor, Department of Faculty Therapy, Allergology, and Immunology, Ural State Medical University, Yekaterinburg, Russia; ssveden@yandex.ru, ORCID: https://orcid.org/0000-0001-5219-9216, eLibrary SPIN: 5248-9958
A.A. Petrovskikh, Student, Ural State Medical University, Yekaterinburg, Russia
Ya.A. Shesterova, Student, Ural State Medical University, Yekaterinburg, Russia

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