Two-year experience with inclisiran at the Sakhalin Regional Clinical Hospital

Mislimova N.N., Korneeva N.V.

1) Sakhalin Regional Clinical Hospital, Yuzhno-Sakhalinsk, Russia; 2) Far Eastern State Medical University, Khabarovsk, Russia

This article presents a two-year experience with inclisiran, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, at the Sakhalin Regional Clinical Hospital. Lipid profile dynamics over a two-year follow-up period in 14 patients are described, demonstrating that triple lipid-lowering therapy (statin, ezetimibe, and inclisiran) reduced total cholesterol by 54%, low-density lipoprotein cholesterol (LDL-C) by 70.4%, and triglycerides by 49.6% from baseline. Information on reported injection site reactions that forced drug discontinuation in two patients is presented. Four clinical cases demonstrating the specific features of Inclisiran use are examined in more detail.

For citations: Mislimova N.N., Korneeva N.V. Two-year experience with inclisiran at the Sakhalin Regional Clinical Hospital. Pharmateca. 2025;32(8):136-141. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2025.8.136-141

Authors’ contribution: N.N. Mislimova — analysis of primary material, manuscript preparation. N.V. Korneeva — publication idea, final editing of the text.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.
Patient Consent for Publication: All patients provided informed consent for the publication of their data.

Keywords

About the Authors

Natalia N. Mislimova, Cardiologist, Regional Vascular Center, Cardiology Department No. 2, Sakhalin Regional Clinical Hospital, Yuzhno-Sakhalinsk, Russia; natalisha1991@mail.ru, ORCID: https://orcid.org/0009-0001-6842-7735
Natalia V. Korneeva, Dr. Sci. (Med.), Associate Professor, Head of the Department of Faculty and Outpatient Therapy with a Course in Endocrinology, Far Eastern State Medical University, Khabarovsk, Russia; Gladkova1982@mail.ru, ORCID: https://orcid.org/0000-0001-9878-180X, eLibrary SPIN: 7817-7670 (corresponding author)

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