Itsenko-Cushing’s disease: yesterday, today, tomorrow

Andreeva A.V., Repetunov G.A., Simakova O.I., Sengurova T.S., Antsiferov M.B.

1) V.V. Veresaev City Clinical Hospital, Moscow Healthcare Department, Moscow, Russia; 2) Endocrinology Dispensary, Moscow Healthcare Department, Moscow, Russia; 3) Russian Medical Academy of Continuous Professional Education, Moscow, Russia

2024 marks the centenary of the first publication with a clinical description of endogenous hypercortisolism syndrome by Russian neurologist Nikolai Mikhailovich Itsenko. Twelve years later, American neurosurgeon Harvey Cushing expanded on this description, and since then, the disease has been named after both scientists. During this time, medicine has made tremendous progress from the first observations to modern pathogenetic drugs. This review is based on the latest international guidelines and new scientific data. It examines the evolution of approaches to the diagnosis and treatment of Itsenko-Cushing’s disease and assesses the problems and prospects for further development.

For citations: Andreeva A.V., Repetunov G.A., Simakova O.I., Sengurova T.S., Antsiferov M.B. Itsenko-Cushing’s disease: yesterday, today, tomorrow. Pharmateca. 2026;33(2):6-12. (In Russ.). DOI: https://dx.doi.org/10.18565/pharmateca.2026.2.6-12

Authors’ contribution: Andreeva A.V. – writing, literature review, editing. Repetunov G.A. – collecting and processing data, writing, literature review, editing. Simakova O.I., Sengurova T.S. – assistance in collecting and processing data. Antsiferov M.B. – editing, approval of the final version of the article.
Conflicts of interest: The authors confirm that they have no conflicts of interest to declare.
Funding: The study was conducted without any sponsorship.

Keywords

About the Authors

A.V. Andreeva, Endocrinologist, Deputy Chief Physician for Medical Affairs, V.V. Veresaev City Clinical Hospital, Moscow, Russia;
andreevaaw@gmail.com, ORCID: https://orcid.org/0000-0002-5097-3033
G.A. Repetunov, Endocrinologist, Endocrinology Dispensary, Moscow, Russia; repetunovgeorgy@gmail.com, ORCID: https://orcid.org/0009-0009-4108-3782 (corresponding author)
O.I. Simakova, Endocrinologist, Head of the Department. Specialized Department, Endocrinology Dispensary, Moscow, Russia; simakova.oi@yandex.ru,
ORCID: https://orcid.org/0009-0002-6297-7418
T.S. Sengurova, Endocrinologist, Endocrinology Dispensary, Moscow, Russia; tsengurova@mail.ru, ORCID: https://orcid.org/0009-0003-7309-962X
M.B. Antsiferov, Dr. Sci. (Med.), Professor, President, Endocrinology Dispensary; Professor, Department of Endocrinology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; antsiferov@rambler.ru, ORCID: https://orcid.org/0000-0002-9944-2997, eLibrary SPIN: 1035-4773