Patient-oriented choice of therapy for inflammatory bowel diseases: a clinical case

I.G. Bakulin, M.S. Zhuravleva, M.M. Bereznitskaya, E.V. Gutman, T.A. Egorova

1) North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia; 2) Leningrad Regional Clinical Hospital, St. Petersburg, Russia

The presented clinical case demonstrates the difficulties in choosing biological therapy for induction and maintenance of remission of Crohn’s disease (CD) and the need for a patient-oriented approach taking into account the patient’s profile and clinical situation. TOne of the effective drugs with a high safety profile, including elderly patients, low immunogenicity, which remains effective in the 2nd and further line of biological therapy, is an anti-cytokine drug, a monoclonal antibody against the p40 subunits of IL-12 and IL-23 ustekinumab.

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About the Authors

I.G. Bakulin, Dr. Sci. (Med.), Professor, Head of the Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after
S.M. Ryss, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia; ORCID: https://orcid.org/0000-0002-6151-2021
Maria S. Zhuravleva, Cand. Sci. (Med.), Associate Professor, Associate Professor at the Department of Propaedeutics of Internal Medicine,
Gastroenterology and Dietetics named after S.M. Ryss, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia;
Mariya.Zhuravleva@szgmu.ru, ORCID: https://orcid.org/0000-0003-4838-5707 (Corresponding author)
M.M. Bereznitskaya, Resident in the specialty «Gastroenterology», Department of Propaedeutics of Internal Diseases, Gastroenterology and Dietetics named after S.M. Ryss, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia; ORCID: https://orcid.org/0009-0007-1407-1378
E.V. Gutman, Head of the Gastroenterology Department, Leningrad Regional Clinical Hospital, St. Petersburg, Russia; ORCID: https://orcid.org/0009-0007-3025-2195
T.A. Egorova, Gastroenterologist, Gastroenterology Department, Leningrad Regional Clinical Hospital, St. Petersburg, Russia; ORCID: https://orcid.org/0009-0001-4114-4882

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