Determination of catecholamine levels in patients with chronic pelvic pain associated with endometriosis

Chernetsova A.S., Sharov M.N., Adamyan L.V., Murvatov K.D., Kiselev S.I., Prokofieva Yu.S., Goncharov I.N.

1) Clinical and Diagnostic Center, Moscow, Russia; 2) Russian University of Medicine, Department of Obstetrics, Gynecology and Reproductive Medicine, Moscow, Russia; 3) Main Military Clinical Hospital of the National Guard Troops of the Russian Federation, Balashikha, Moscow Region, Russia; 4) Filatov City Clinical Hospital No. 15, Moscow, Russia; 5) Medical Center of the Goncharov Medical Dynasty, Moscow, Russia

Background. Chronic pelvic pain in endometriosis is accompanied by high levels of stress and anxiety.
Objective. Evaluation of the norepinephrine, adrenaline levels in the peripheral blood of patients with chronic pelvic pain and endometriosis.
Methods. A comparative analysis of the results of assessing blood catecholamine levels and stress levels was performed in 40 women (18-45 years old) with endometrioid ovarian cysts suffering from chronic pelvic pain and neuropathy.
Study design: comparative prospective study.
Results. Patients with chronic pelvic pain associated with endometriosis had high blood catecholamine levels compared with the control group and the group with painless endometriosis (p < 0.05).
Conclusion. High levels of stress, anxiety and depression in patients with CPP and endometriosis maintain high blood levels of adrenaline and norepinephrine, aggravating chronic pain.

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About the Authors

Corresponding author: Anna S. Chernetsova, Obstetrician-Gynecologist, Clinical and Diagnostic Center, Moscow, Russia; ana550@mail.ru

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