A new method for early diagnostics of acute mesenteric circulation disorder

Gadzhimuradov R.U., Dibirov M.D., Parfenov I.P., Khalidov O.Kh., Sidorova D.I., Bobylev A.A., Fomin V.S.

1) Russian University of Medicine, Department of Surgical Diseases and Clinical Angiology, Moscow, Russia; 2) Veresaev City Clinical Hospital, Moscow, Russia

Acute circulatory disorder in the mesenteric vessels is a pathology with high mortality rates, reaching 95%. One of the reasons is that during the diagnostic window corresponding to intestinal ischemia lasting up to 12 hours, most district hospitals in emergency surgery settings conduct routine tests that are not highly specific to this pathology and force the doctor to adopt a wait-and-see approach. A new laboratory indicator is intestinal protein binding fatty acids (I-FABP). When the integrity of the enterocyte membrane is compromised, it enters the venous system from the intracellular space. Thus, with the development of acute mesenteric ischemia and, as a consequence, damage to enterocytes, the I-FABP level in urine and blood tests increases significantly. The sensitivity and specificity of the marker, according to various authors, range from 80 and 85% to 90 and 89%, respectively. Laboratory determination of blood serum I-FABP level in patients with suspected acute mesenteric ischemia will reduce the diagnostic time, select the optimal treatment tactics, improve treatment results and, accordingly, reduce mortality from this pathology.

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About the Authors

Corresponding author: Vladimir S. Fomin, Dr. Sci. (Med.), Associate Professor, Department of Surgical Diseases and Clinical Angiology, Russian University of Medicine; Veresaev City Clinical Hospital, Moscow, Russia; wlfomin83@gmail.com