Molecular biological transformation of the pelvic floor during pregnancy and the postpartum period (literature review)
An analysis of literature data on epidemiology, morphofunctional changes and molecular mechanisms of remodeling of the connective tissue of the woman’s reproductive system during pregnancy, childbirth and the postpartum period was carried out. The search and analysis of publications in the PUBMED, ScienceDirect, eLIBRARY.RU databases was carried out. The importance of genes that control the processes of synthesis and degradation of connective tissue, in particular the genes for collagen, fibulin and lysyl oxidase-like protein, is described. The place of matrix metalloproteinases and their tissue inhibitors in the proteolytic degradation of the extracellular matrix of connective tissue is discussed. Modern data on methods for assessing the function and strength of the pelvic floor muscles in women during pregnancy are presented, and modern possibilities for conservative treatment of women with pelvic floor dysfunction namely, the use of high-frequency radiotherapy with a detailed description of the mechanisms of effectiveness, are revealed.A.V. Varlamova, A.A. Mikhelson, Yu.A. Semenov, O.A. Melkozerova, M.V. Lazukina
Keywords
pelvic floor dysfunction
perineal trauma
metalloproteinases
fibulin
lysyl oxidase-like protein
dynamic quadripolar radiofrequency
About the Authors
Corresponding author: Anastasia L. Varlamova, PhD student, Obstetrician-Gynecologist, Ural Research Institute of Maternity and Infancy Protection, Yekaterinburg, Russia; anastasiia.var@yandex.ruSimilar Articles
