Efficiency of a fixed combination of insulin glargine and lixisenatide in everyday clinical practice

O.S. Elsukova, E.A. Nikitina

Kirov State Medical University, Kirov, Russia

Background: In order to intensify therapy, hypoglycemic drugs that provide not only optimal glycemic control, but also have non-glycemic properties can be used.
Objective. Evaluation of the glycemic and non-glycemic effects of the fixed combination (FC) of insulin glargine and lixisenatide in patients with type 2 diabetes mellitus (DM2) in everyday clinical practice over 24 months of follow-up.
Materials and methods. The study included 35 DM2 patients who did not achieve compensation of carbohydrate metabolism during previous hypoglycemic therapy. Patients were prescribed the FC of insulin glargine and lixisenatide. Anthropometric data, parameters of carbohydrate metabolism and lipid spectrum, and hemodynamic parameters were analyzed initially and after 24 months. Additionally, the frequency of symptomatic hypoglycemic states and severe hypoglycemia was assessed.
Results. After 24 months of treatment with FC of insulin glargine and lixisenatide, glycemic control parameters were improved without weight gain and hypoglycemic episodes, lipid metabolism parameters with a positive effect on systolic blood pressure.
Conclusion: FC of insulin glargine and lixisenatide not only provide optimal glycemic control, but are also capable of exerting a number of pleiotropic effects in the form of weight loss, improved lipid parameters and systolic blood pressure.

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About the Authors

Olga S. Elsukova, Cand. Sci. (Med.), Associate Professor at the Department of Hospital Therapy, Kirov State Medical University, Kirov, Russia; oselsukova@mail.ru, ORCID: https://orcid.org/0000-0002-2341-9491
Elena A. Nikitina, Cand. Sci. (Med.), Associate Professor, Department of Internal Medicine, Kirov State Medical University, Kirov, Russia; nikitinae1991@mail.ru, ORCID: https://orcid.org/0000-0002-7316-3252 (corresponding author)

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