Postcovid alopecia: from the study of pathogenesis to the choice of therapy

A.Yu. Nikolaeva, O.A. Bitkina, I.V. Kosheleva, M.V. Presnyakova, K.N. Kontorshchikova, A.A. Dmitrieva, P.V. Peretyagin, A.A. Tsyganova

1) Privolzhsky Research Medical University, Nizhny Novgorod, Russia; 2) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 3) N.I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod, Russia

Background. A review of the literature data on the problem of alopecia associated with a new coronavirus infection is presented. Information on the etiological and pathogenetic aspects of post-covid alopecia, the role of the immune response and endothelial dysfunction is discussed.
Objective. Assessment of the state of the hemostasis system in patients with postcovid alopecia by thrombodynamics (TD).
Methods. The study included 49 women who were divided into 3 groups: group 1 (n=26) – patients with post-covid alopecia, group 2 (n=13) - patients with alopecia who did not have coronavirus infection, group 3 (n=10) – without manifestations of alopecia. Changes in the indicators of the TD test were detected in patients with alopecia who had a coronavirus infection.
Conclusion. Reports of the development of microcirculatory dysfunction in patients with COVID-19, activation of coagulation, characterized by thrombotic microangiopathy and endotheliitis, are confirmed by the results of studies that revealed disorders of the hemostasis system of prothrombotic orientation (according to the TD test) in most patients with postcovid alopecia. The TD hemostasis test can be an important tool for monitoring the condition of patients with postcovid alopecia, correcting and evaluating the effectiveness of therapy.

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About the Authors

Corresponding author: Anastasia Yu. Nikolaeva, PhD student, Department of Skin and Venereal Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia; ayunikolaeva@yandex.ru

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