Lipid peroxidation in the body of patients with tuberculosis

E.K. Rumyantsev, N.M. Krasnova, V.M. Nikolaev, E.S. Prokopiev, M.P. Kirillina, D.A. Sychev

1) Yakutsk Scientific Center for Complex Medical Problems, Yakutsk, Russia; 2) M.K. Ammosov North-Eastern Federal University, Yakutsk, Russia; 3) E.N. Andreev Scientific and Practical Center “Phthisiology”, Yakutsk, Russia; 4) Russian Medical Academy of Continuous Professional Education, Moscow, Russia

This work was aimed to the comparative assessment of the activity of free-radical lipid oxidation in the body of tuberculosis patients and healthy volunteers. The study involved 76 patients with drug-susceptible and drug-resistant pulmonary tuberculosis (mean age 42.97±15.38 years) and 40 relatively healthy volunteers (mean age 42.45±11.56 years). Venous blood samples were used for the study. Malondialdehyde concentration was determined in blood serum (Costa et al. [2006]); the activity of enzymes of the glutathione system – glutathione peroxidase (Paglia et al., [1967]), glutathione-S-transferase (Habig et al. [1974]), glutathione reductase (Mannervik et al. [1978]) and the concentration of reduced glutathione (Tietze et al. [1969]) – was determined in erythrocyte hemolysate According to the results of our study, in the body of patients with tuberculosis, there is an increase in the intensity of free-radical oxidation against the background of a decrease in antioxidant protection. The intensity of free-radical lipid oxidation and the indices of the glutathione system among patients with drug-sensitive and drug-resistant pulmonary tuberculosis did not differ significantly.

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About the Authors

Corresponding author: Egor K. Rumyantsev, Junior Researcher at the Arctic Medical Center, Yakutsk Scientific Center for Complex Medical Problems, Yakutsk, Russia; Tzeentch1993@mail.ru; eLibrary SPIN: 1081-6314

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