Characterization of the plasminogen activator inhibitor type 1 gene (PAI-1) and its role in the development of arterial thrombosis

N.V. Izmozherova, A.A. Popov, I.P. Antropova, L.I. Kadnikov, A.O. Polyanok, V.E. Ispavsky

Ural State Medical University, Department of Pharmacology and Clinical Pharmacology, Yekaterinburg, Russia

Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of the fibrinolytic system in vivo. The results of modern studies do not allow to form an unambiguous opinion about the degree of influence of the PAI-1 level and its polymorphism (4G/5G, 4G/4G) on the incidence of thrombotic events in the arterial bed. In this regard, the purpose of this review was to compile a general characterization of the properties of PAI-1, as well as to establish the role of its polymorphism in the development of thrombosis, depending on individual physiological and ethnic factors, as well as promising directions in its further study.

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About the Authors

Corresponding author: Leonid I. Kadnikov, PhD student, Department of Pharmacology and Clinical Pharmacology, Ural State Medical University, Yekaterinburg, Russia; kadn-leonid@mail.ru

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